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The MDL-SHPVP will be developed and a clustered randomised controlled trial will be conducted to evaluate the effects of the MDL-SHPVP and to examine whether the effect of the MDL-SHPVP on the rate of HPV vaccine uptake 1 year after intervention is mediated by parents'/guardians' and female adolescents' HPV knowledge, attitudes and beliefs, adolescents' intention to receive HPV vaccination and vaccine acceptance among their parents/guardians.
2520 adolescents and their parents or guardians from 18 local secondary day schools will be recruited. Multicomponent interventions will be offered to the intervention schools. To build and strengthen the community capacity in health promotion, a team of volunteers will be established to raise awareness of HPV, cervical cancer and HPV vaccine.
Data will be collected at baseline, 1 month and 1 year after intervention. The mixed-effects model will be used to compare the differential changes for each of the primary and secondary outcomes across time between the two groups.
The project is expected to instil a more accurate understanding of HPV and HPV vaccination and support the decision to undergo vaccination.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention schools | Experimental | A 2-hour education session with multicomponent interventions including education sessions with small group dialogues with a registered nurse and trained healthcare and lay volunteers and educational computer games |
|
| Control schools | Other | Control and usual care |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MDL-SHPVP | Other | A 2-hour education session with multicomponent interventions including education sessions with small group dialogues with a registered nurse and trained healthcare and lay volunteers and educational computer games |
| Measure | Description | Time Frame |
|---|---|---|
| Female adolescents' uptake of the HPV vaccine | Self report uptake of the HPV vaccine by the female adolescents in the past 12 months. | 1 year post-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change of female adolescents' intention to receive HPV vaccination | A 10-point Likert scale will be used to measure the intention indicates "Definitely". 1 indicates "Definitely not" and 10 indicates "Definitely". Higher value means higher intention. | baseline, 1 month post-intervention |
| Change of vaccine acceptance among parents/guardians |
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Inclusion Criteria:
Exclusion Criteria:
The HPV vaccination mainly targets at female in Hong Kong, with the inclusion in Hong Kong Child Immunisation Programme to eligible female students at Primary 5 and 6 from 2019/2020 school year.
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| Name | Affiliation | Role |
|---|---|---|
| Pak Chun Janita Chau, PhD | Chinese University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Chinese University of Hong Kong | Shatin | Hong Kong |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41068722 | Derived | Lo SHS, Chau JPC, Choi KC, Butt L, Lui GCY, Lee VWY, Lau AYL. Effects of an educational health promotion intervention to improve human papillomavirus vaccination acceptance and uptake among adolescent girls: a cluster randomized controlled trial. BMC Public Health. 2025 Oct 9;25(1):3419. doi: 10.1186/s12889-025-24511-4. | |
| 32925744 |
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| ID | Term |
|---|---|
| D030361 | Papillomavirus Infections |
| D015438 | Health Behavior |
| ID | Term |
|---|---|
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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| 30-minute educational video | Other | A 30-minute education video (DVD) on HPV, cervical cancer and the HPV vaccine that is designed to enhance HPV vaccine acceptance |
|
Precaution Adoption Process Model will be used to measure the vaccine acceptance. |
| baseline, 1 month post-intervention |
| Change of female adolescents' and parents'/ guardians' HPV knowledge | HPV General and HPV Vaccine Knowledge Scale will be used to measure the knowledge.1 point will be given to each correct answer and 0 points will be given to each incorrect or "Don't know" answer. Higher scores mean more HPV knowledge. | baseline, 1 month post-intervention |
| Change of female adolescents' HPV attitudes and beliefs | Carolina HPV Immunisation Attitudes and Beliefs Scale will be used to measure the attitudes and belief. An 11-point Likert scale will be used, with 0, 5, 7 and 10 indicate "strongly disagree," "somewhat disagree," "somewhat agree" and "strongly agree" respectively, or indicate "extremely ineffective, "somewhat ineffective," "somewhat effective" and "extremely effective" respectively. Higher values mean stronger agreement with the statement and less agreement with or endorsement of HPV vaccination. Five items will be reverse-coded. | baseline, 1 month post-intervention |
| Change of parents'/ guardians' HPV attitudes and beliefs | Carolina HPV Immunisation Attitudes and Beliefs Scale will be used to measure the attitudes and belief. A 4-point Likert scale will be used. 1,2,3 and 4 indicate "strongly disagree," "somewhat disagree," somewhat agree," and "strongly agree" respectively. Higher values indicate stronger agreement with the statement. | baseline, 1 month post-intervention |
| Chau JPC, Lo SHS, Choi KC, Lee VWY, Lui GCY, Chan KM, Lau AYL. Effects of a multidisciplinary team-led school-based human papillomavirus vaccination health-promotion programme on improving vaccine acceptance and uptake among female adolescents: A cluster randomized controlled trial. Medicine (Baltimore). 2020 Sep 11;99(37):e22072. doi: 10.1097/MD.0000000000022072. |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D014412 | Tumor Virus Infections |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |