Gut Bacteria and Brain of the Baby

Gut Bacteria and Brain of the Baby: to Link up the Dynamic of Gut Colonization in Preterms Born at Gestational Age of 30-326/7 Weeks and Their Psychomotor Development at 2 Years

The project is a prospective French population based cohort. A hundred moderate preterms born at GA30-326/7 will be enrolled for a longitudinal follow-up up to 2 years of corrected age. Eligible neonates will be those born at 30-326/7 weeks of gestation admitted to the neonatal intensive care unit of Rennes Hospital, including transferred infants during the first day of life. The infants will be followed up to the corrected age of 2 years by pediatricians.

Inclusion Criteria:

• Preterms born at gestational age of 30-326/7 weeks of amenorrhea
• Preterms born in Rennes hospital or preterms born in another hospital but moved to Rennes hospital during the first 24 h of postnatal life
• Parents or holder of the parental authority who give in writing their free, prior and informed consent for recruitment of their baby who has a social security system
• Mother of the baby who gives in writing her free, prior and informed consent to be involved in the present study
• Mother of the baby who has a social security system

Exclusion Criteria:

• Preterms born with a genetic disease
• Preterms born with a digestive defect
• Uncompetent parents under the protection of guardianship or tutelage services