Fertility Restoration Using Autologous Mesenchymal Stem Cells

Fertility Restoration Using Autologous Adipose Tissue Derived Mesenchymal Stem Cells

Treatment of the patients with scarring and adhesions in the uterus resulting from caesarean section or chronic inflammation in the mucosa of the uterus and fallopian tubes and preventing the occurrence of these effects in the future

The aim of the project is to develop a biomedical cell product based on autologous adipose tissue derived mesenchymal stem cells and a biodegradable carrier for highly effective treatment and prevention of scarring and adhesions in the uterus acquired as a result of cesarean section or chronic inflammatory processes in the uterine mucosa and fallopian tubes; to conduct the clinical trials of the biomedical cell product in the treatment of uterus scarring and infertility in women.

Inclusion Criteria:

• chronic endometritis
• postoperative uterus scars
• uterine synechia
• fallopian tube obstruction
• absence of acute inflammation in the uterus

Exclusion Criteria:

• Patients with genetic diseases of muscle and connective tissue;
• Patients with malformations of the uterus;
• Acute and chronic infectious diseases: HIV, mycoplasma infection, hepatitis B and C, syphilis; autoimmune diseases; oncological diseases; continuous hormonal therapy with cytostatics corticosteroids; acute noncommunicable diseases;
• mental disorders;
• Drug or alcohol addiction;
• Benign tumors of uterus and appendages;
• Hypersensitivity to any component of the studied biomedical cell product.