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The purpose of this study is to evaluate the effects of a direct current applied transcranial over two cortical areas on healthy volunteers' pain processing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| M1 stimulation | Active Comparator | A 20 minutes 1mA direct current stimulation over left M1. |
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| M1+DLPFC stimulation | Active Comparator | A 20 minutes 1mA direct current stimulation over left M1 and 1mA direct current stimulation over left DLPFC. |
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| Sham stimulation | Sham Comparator | A 20 minutes sham stimulation where the device only is working first 30s and last 30s of the intervention and have a 10 seconds fade out in intensity at each ramp. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial direct current stimulation | Device | Direct current application over the scalp to stimulate and change the excitability of the cortical areas underneath the electrodes (in this case left primary motor cortex and left dorsolateral prefrontal cortex). |
| Measure | Description | Time Frame |
|---|---|---|
| Conditioned Pain Modulation | Pain pressure threshold change after a painful ischemic stimulus | Pre-intervention and immediately after treatment |
| Pain pressure algometer temporal summation | Change in pain perceived between the first and tenth painful pressure stimulus | Pre-intervention and immediately after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Pain pressure threshold | Measurement of pressure applied until the perception of pain | Pre-intervention and immediately after treatment |
| Pain pressure tolerance | Measurement of maximal painful pressure tolerate using a pressure algometer |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Josue Fernandez Carnero, PhD | Universidad Rey Juan Carlos | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad Rey Juan Carlos | Alcorcón | Madrid | 28922 | Spain |
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| Label | URL |
|---|---|
| Rey Juan Carlos University | View source |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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Three groups cross over study with two intervention groups and one sham group.
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| Pre-intervention and immediately after treatment |
| Neural mechanosensitivity | Measurement of range of motion achieved until the perception of tension | Pre-intervention and immediately after treatment |
| Cold hyperalgesia with a cold pack | Pain rated in a visual analogue scale after 10 seconds of a cold stimulus | Pre-intervention and immediately after treatment |
| Isometric grip strength | Maximal pressure achieved in a isometric gripping task | Pre-intervention and immediately after treatment |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |