Heterozygous Individuals for AGXT and Kidney Stones

Heterozygous Individuals for AGXT and Kidney Stones

This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies.

Inclusion Criteria:

• at least 18 years of age
• history of calcium oxalate stones
• heterozygous mutation of the AGXT gene, as evidenced by results from the Invitae Nephrolithiasis Panel
• willingness to comply with a controlled diet for five days

Exclusion Criteria:

• pregnant individuals
• individuals who are currently breast feeding