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| Name | Class |
|---|---|
| Singapore General Hospital | OTHER |
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Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally. PA is caused by excessive release of a hormone (aldosterone) from the adrenal glands, which can be unilateral (one gland) or bilateral (both glands).
It has been shown that excess aldosterone has other harmful effects in addition to hypertension, such as directly affecting the heart, blood vessels, kidneys, leading to increased cardiovascular morbidity and mortality. This is supported by studies showing reversal of these effects after treatment for PA.
The investigators aim to assess the long-term cardiovascular, and renal outcomes of patients with PA, compared to patients with essential hypertension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Surgery | Patients treated with surgery |
| |
| Medications | Patients treated with mineralocorticoid antagonists or potassium sparing diuretics for primary aldosteronism |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Unilateral adrenalectomy in patients with unilateral disease | Procedure | Unilateral adrenalectomy in patients with unilateral disease |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in systolic blood pressure before and after treatment | change in systolic blood pressure | six months after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| change in diastolic blood pressure before and after treatment | change in diastolic blood pressure | six months after treatment |
| change in systolic blood pressure before and after treatment | change in systolic blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with suspected primary aldosteronism managed at referral centre for suspected primary aldosteronism
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Troy Puar, MRCP | Contact | 67888833 | troy_puar@cgh.com.sg |
| Name | Affiliation | Role |
|---|---|---|
| Troy Puar, MRCP | Changi General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Changi General Hospital | Recruiting | Singapore | 529889 | Singapore |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33058182 | Derived | Puar TH, Loh LM, Loh WJ, Lim DST, Zhang M, Tan PT, Lee L, Swee DS, Khoo J, Tay D, Tan SY, Zhu L, Gani L, King TF, Kek PC, Foo RS. Outcomes in unilateral primary aldosteronism after surgical or medical therapy. Clin Endocrinol (Oxf). 2021 Feb;94(2):158-167. doi: 10.1111/cen.14351. Epub 2020 Oct 26. |
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Sharing of anonymised pooled data
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| through study completion, an average of 5 years |
| change in diastolic blood pressure before and after treatment | change in diastolic blood pressure | through study completion, an average of 5 years |
| cardiovascular outcome | incidence of new cardiovascular events including acute myocardial infarction, revascularisation percutaneously, coronary artery bypass graft, stroke, admission for congestive cardiac failure, atrial fibrillation | through study completion, an average of 5 years |
| chronic kidney disease | incidence of worsening chronic kidney disease, decline of glomerular filtration rate by 15ml/min from at least 60m/min | through study completion, an average of 5 years |
| Renal Progression | rate of decline of glomerular filtration rate | through study completion, an average of 5 years |
| variables that predict unilateral disease | Identify variables that are more common in patients with unilateral disease | through study completion, an average of 5 years |
| variables that predict blood pressure response | Identify variables that are more common in patients with positive blood pressure response | through study completion, an average of 5 years |
| ID | Term |
|---|---|
| D006929 | Hyperaldosteronism |
| D051436 | Renal Insufficiency, Chronic |
| D007008 | Hypokalemia |
| ID | Term |
|---|---|
| D000308 | Adrenocortical Hyperfunction |
| D000307 | Adrenal Gland Diseases |
| D004700 | Endocrine System Diseases |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014883 | Water-Electrolyte Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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