Novel Dementia Biomarkers

Investigating the Potential of Novel Dementia Biomarkers - an MRI, fNIRS and EEG Study

The study will investigate structural and functional characteristics of the brain of dementia patients compared to healthy controls in order to get a better insight into importance of early biomarkers for the diagnosis of Alzheimer's dementia. The methods for obtaining biomarkers incude magnetic resonance imaging (MRI), near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), electrocardiography (ECG) and neurophyshological assessments. Special parameters are being studied that have already been shown to detect changes in the early stages of Alzheimer's dementia.

Inclusion Criteria:

• Clinically diagnosed MCI patients and matched healthy controls

Exclusion Criteria:

• Metal in body and tatoos;
• Other chronic systemic neurological, cardiologic, metabolic or musculo-skeletal diseases which have been proven to influence the outcome variables
• Alcohol abuse
• Colour blindness
• Pregnancy
• Surgery in the last 6 months
• Uncorrected vision