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| Name | Class |
|---|---|
| Beijing Tiantan Hospital | OTHER |
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This study aimed to analyze the connectivity alterations in brain networks of LGG patients with epilepsy who take levetiracetam at short-term preoperatively.
Glioma-related epilepsy (GRE) is a very common symptom in patients with diffuse gliomas. Approximately 60% of patients with low-grade gliomas (LGGs) and 40-64% of patients with high-grade gliomas presented with GRE at the onset. Although beneficial for the control of GRE, the overall therapeutic effect was unsatisfied and over 20% of patients still suffered from seizures.
GRE was found to be associated with brain network and functional connectivity. And it has been reported that temporal lobe seizures could induce functional connectivity and decreased network efficiency of brain networks. However, the alterations in functional networks induced by GRE were still unclear. And LGG patients with GRE usually take levetiracetam (LEV) preoperatively, which could effectively reduce abnormal spike activity and further cause connectivity alterations. This makes it more complex to reveal the connectivity alterations of brain networks in LGG patients with GRE.
This study aimed to collect the resting-state functional MRIs of 30 LGG patients who presented with GRE at the onset. Through further applied graph theory analysis, investigators tend to reveal the connectivity alterations of brain networks caused by levetiracetam. The findings of this study will provide a theoretical basis for further study of connectivity alterations of brain networks in patients with GRE.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with LEV application | LGG patients with GRE take levetiracetam less than 1 month preoperatively. These patients take levetiracetam tablets twice a day, and one tablet at a time. Each levetiracetam tablet contains 500mg levetiracetam. | ||
| Patients without LEV application | LGG patients with GRE do not take any medicine or receive any treatment preoperatively. |
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| Measure | Description | Time Frame |
|---|---|---|
| The connectivity alterations of brain networks in patients with and without levetiracetam application | Graph theory analysis is used to delineate topological networks with resting-state functional MRIs and investigated the characteristics of functional networks. Global and nodal topological properties of brain networks are calculated in the two groups of patients. The difference of topological properties of brain networks between patients with and without levetiracetam application are analyzed using t-test or chi-square test according to the type of data. | through study completion, an average of 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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All patients with LGG presented GRE, take levetiracetam less than 1 month; or do not take any medicine and receive any treatment.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tao Jiang, MD and PhD | Contact | +86-010-67021832 | taojiang1964@163.com | |
| Lianwang Li, MD | Contact | +86 18810647541 | ttyyllw@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Neurosurgical Institute and Beijing Tiantan Hospital | Beijing | Beijing Municipality | 100070 | China |
We do not plan to share individual participant data with other researchers
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| ID | Term |
|---|---|
| D005910 | Glioma |
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
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| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |