Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration
Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration
In this study researchers want to learn more about changes in visual acuity (clarity of vision) with a high dose treatment with Aflibercept (Eylea) in patients suffering from neovascular age-related macular degeneration (nAMD). Neovascular AMD is an eye disease that causes blurred vision or a blind spot due to abnormal blood vessels that leak fluid or blood into the light sensitive lining inside the eye (retina). The fluid buildup causes the central part of the retina (macula) responsible for sharp, straight-ahead vision to swell and thicken (edema), which distorts vision.
Inclusion Criteria:
Additional inclusion criteria for Year 3:
Exclusion Criteria:
Phoenix, Arizona 85021-8865, United States
Mountain View, California 94040, United States
San Diego, California 92037, United States
Gainesville, Florida 32607-2557, United States
St. Petersburg, Florida 33711, United States
Albuquerque, New Mexico 87109, United States
The Woodlands, Texas 77384, United States
Burlington, Vermont 05401-1473, United States
Buenos Aires, Ciudad Auton. de Buenos Aires C1015ABO, Argentina
Buenos Aires, Ciudad Auton. de Buenos Aires C1120AAN, Argentina
Sofia, 1618, Bulgaria
Beijing, Dongcheng District 100005, China
Ningxia, Ningxia 750002, China
Plzen-Lochotin, 323 00, Czechia
Kahoku-gun, Ishikawa-ken 920-0293, Japan
Kita-gun, Kagawa-ken 761-0793, Japan
Nakagami, Okinawa 903-0215, Japan
Osakasayama-shi, Osaka 589-8511, Japan
Bunkyo-ku, Tokyo 113-8655, Japan
Chuoku, Tokyo 104-8560, Japan
Edogawa-ku, Tokyo 134-0088, Japan
Itabashi-ku, Tokyo 174-0071, Japan
Meguro-ku, Tokyo 152-8902, Japan
Shinjuku-ku, Tokyo 160-8582, Japan
Shinjuku-ku, Tokyo 162-8666, Japan
Porto, 4434-502, Portugal
Kropyvnytskyi, 25006, Ukraine