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This study evaluates the role of advanced US technology in assessing renal transplants as screening tools such as 3D Ultrasound, Ultrasound SWE, and MFI besides current ultrasound conventional metheds.
This study will focus on monitoring renal after transplantation using all US advanced technology.
Aim one will concentrate on the 3D US in assessing artery stenosis (TRAS) compared to the gold standard.
Aim two focuses on will concentrate on Ultrasound elastography in assessing renal stiffness.
Aim three will compare US colour modes such as PD, CD and MFI to assess renal perfusion in three groups.
Duration: 18 Months; participants will have a patient information sheet; once they are happy to participate, consent will be obtained.
Study data will be entered into a database encrypted and stored in the department. Only the study principal investigator (PI) will know the study database password.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transplanted kidney | No intervention is required. Routine Doppler assessment + 3D scan + Shear wave elastography + MicrFlow Imaging will be immediately recorded afterwards |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3D imaging | Device | The study will focus on the accuracy of ultrasound technology in assessing renal transplants. The entire assessment should not take more than 25 minutes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Peak systolic velocity (cm/s). | Pean of the blood flow velocities in the artery/ vein peak systolic velocity ≥200 cm/s velocity difference between pre- and post-stenotic segments of 2:1 | 12 weeks |
| Peak systolic velocity ratio (PSVR). | High velocity flow at the stenosis site divided by a reference velocity (normal before stenosis) | 12 weeks |
| Resistive Index (RI). | An RI less than 0.7 to 0.8 is considered normal, more than that it is indicator of transplant dysfunction. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Volumetric stenosis. | Plaque volume is calculated automatically with the aid of software with a package of 3D laptop. | 12 weeks |
| 3D GSM. | Plaque volume is calculated automatically with the aid of software with a package of 3D laptop. |
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INCLUSION CRITERIA
EXCLUSION CRITERIA
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Adult patients having /had kindey transplant
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| Name | Affiliation | Role |
|---|---|---|
| Mohammed Aslam, PhD | Academic Supervisor | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Imperial College London | London | W12 0HS | United Kingdom |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Sep 29, 2023 | |
| Reset | Apr 5, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Sep 29, 2023 | Apr 5, 2024 |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D051436 | Renal Insufficiency, Chronic |
| D012078 | Renal Artery Obstruction |
| D005355 | Fibrosis |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D021621 | Imaging, Three-Dimensional |
| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| 12 weeks |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |