Aim of the work This study aims at; Early detection of disruption and leakage of intestinal anastomotic sites whether small or large intestine by using biochemical markers as predictors and indicators of leakage with application of scoring scale to assess presence or absence of leakage.

Inclusion Criteria:

• Any patient with intestinal or colonic anastomosis either elective or emergent.

Exclusion Criteria:

• Patients with inflammatory bowel disease will be excluded because this could influence plasma levels of inflammatory biomarkers.
• patients using corticosteroids
• Patients unfit for anaesthesia, those having collagen diseases or hematological disorders.