Binding of Lu AG06466 in the Brain in Healthy Men

Interventional, Open-label, Position Emission Tomography (PET) Study Investigating MAGL Occupancy After Single and Multiple Oral Doses of Lu AG06466 in Healthy Male Subjects

A study to learn how Lu AG06466 and one of its break down products binds in the brain after single and repeated dosing

The study will be conducted in two Parts. Part A: cross over, fed/fasted determined by randomized sequence Part B: sequential group

PET scans will be used to quantify MAGL occupancy

Inclusion Criteria:

• body weight ≥60 kg.
• body mass index ≥18.5 and ≤27 kg/m2.
• waist circumference ≤94 cm.
• The subject has a normal sMRI performed during the screening period.
• The subject is suitable for radial artery blood sampling and cannulation as demonstrated by the Allen test.
• Subject must be healthy as assessed using detailed medical history, laboratory tests, and physical examination.
• The subject must make use of contraception.

Exclusion Criteria:

• The subject is left handed.

Other in- and exclusion criteria may apply