Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Beijing Haidian Hospital | OTHER |
| Aerospace 731 Hospital | OTHER |
| Beijing Breatha Biological Technology Co., Ltd, Beijing | UNKNOWN |
| The First Affiliated Hospital of Zhengzhou University |
Not provided
Not provided
Not provided
Not provided
Early detection is critical to improve the overall survival of lung cancer. Endogenous volatile organic compounds (VOCs) can be derived from many different metabolic pathways. On the other hand, cancer cells have different metabolism patterns compared with normal cells. Thus, detecting VOCs in exhaled breath using highly sensitive mass spectrometry would be a promising approach for lung cancer detection.
Endogenous volatile organic compounds (VOCs) can be derived from many different metabolic pathways. VOCs can be transported to the alveoli through the blood circulation and expelled by exhalation. Changes in VOCs production, clearance, and alterations in lung air-blood exchange functions can lead to aberrant VOCs profiles in the exhaled breath. Testing exhaled breath has the advantages of being completely non-invasive and easy to collect, and has been considered as a perfect approach for disease diagnoses and therapeutic monitoring. Many clinical studies have found that VOCs in exhaled breath are closely related to disease status. Specific VOCs alterations have been identified in many tumors, especially lung cancer.
In this study, we use a highly sensitive mass spectrometry to detect exhaled VOCs of lung cancer patients and healthy people. A lung cancer diagnosis model based on mass spectrometry data and support vector machine will be initially established and validated.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Surbery | Patients who with pulmonary nodules in computed tomography and planned to receive thoracic surgery will be included. And those who have other types of cancer, received anti-tumor treatment before surgery, liver disease, or infections will be excluded. |
| |
| Healthy Controls | Adult participants (>18 yr) who plan to receive annual physical examination and low-dose computed tomography will be included. And those who have history cancers, received anti-tumor treatment before surgery, liver disease, or infections will be excluded. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Breath test | Diagnostic Test | Exhaled breath of each participant will be collected with air bags and directly detected by a high-resolution high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS). |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic sensitivity of exhaled breath | Using pathologic diagnosis of lung cancer as gold standard, diagnostic sensitivity of exhaled breath will be calculated | 2 year |
| Diagnostic specificity of exhaled breath | Using pathologic diagnosis of lung cancer as gold standard, diagnostic specificity of exhaled breath will be calculated | 2 year |
| Positive predictive value of exhaled breath | Using pathologic diagnosis of lung cancer as gold standard, positive predictive value of exhaled breath will be calculated | 2 year |
| Negative predictive value of exhaled breath | Using pathologic diagnosis of lung cancer as gold standard, negative predictive value of exhaled breath will be calculated | 2 year |
| Diagnostic accuracy of exhaled breath | Using pathologic diagnosis of lung cancer as gold standard, diagnostic accuracy of exhaled breath will be calculated | 2 year |
Not provided
Not provided
Inclusion Criteria for inpatient :
Inclusion Criteria for controls :
Exclusion Criteria:
Not provided
Not provided
Not provided
Eligible inpatients will be recruited from Department of Thoracic Surgery, Peking University People's Hospital and Beijing Haidian Hospital.
For healthy controls, eligible participants will be recruited from those who receive planned annual physical examination at Aerospace 731 Hospital.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Mantang Qiu, M.D | Peking University People's Hospital Thoracic Surgery Department | Study Chair |
| Zuli Zhou, M.D | Peking University People's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University People's Hospital | Beijing | Beijing Municipality | 100044 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
Not provided
Not provided
| ID | Term |
|---|---|
| D001944 | Breath Tests |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
Not provided
Not provided
| OTHER |
| Jiangsu Cancer Institute & Hospital | OTHER |
Not provided
Not provided
Not provided
Exhaled breath samples will be collected with air bags.
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |