Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Agence de La Biomédecine | OTHER_GOV |
| Eurotransplant | UNKNOWN |
| United Network for Organ Sharing | UNKNOWN |
| Deutsche Stiftung Organtransplantation |
Not provided
Not provided
Not provided
Not provided
Not provided
End-stage organ failure is estimated to affect more than 4 to 6 million persons worldwide. In 2018, transplant systems across the globe enabled around 150,000 patients to benefit from a kidney, heart, lung, liver, or other solid organ, a number that was far less than the demand. According to data from the World Health Organization, more than 1,500,000 persons live with a transplanted organ worldwide. In the US, approximately 40,000 patients receive an organ transplant every year, but 120,000 still remain waitlisted for transplantation today, with 7,600 dying annually while waiting for an organ transplant. A similar lack of organs and high death rates on the waiting list affect patients in Europe and many other countries.
As nations adjust to new realities driven by the coronavirus (COVID-19) outbreak, many health care providers, institutions and patients are concerned about the potential impact that COVID-19 will have on organ donation and transplantation. One concern is that transplant recipients may have a greater susceptibility to infection and greater viral burden. A second concern is that hospitals will lack the resources in terms of staff and equipment to care for recipients after transplantation, who often require intensive care and multispecialty management.
Because of the overwhelming healthcare system burden, a dramatic negative effect on worldwide organ donation and transplantation is anticipated, but has not been measured. Our objective was to quantify the worldwide impact of COVID-19 pandemic on organ donation and transplantation and consequences for waitlisted patients.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| France | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. | ||
| Spain | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. | ||
| Portugal | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. | ||
| Croatia | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. | ||
| Germany | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. | ||
| Italy | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Organ transplantation activity during COVID-19 pandemic | Overall deceased donor transplantation performed during the COVID-19 pandemic. Stratified analysis by deceased donor type (Kidney, lung, Liver, heart), and combined transplantations during the COVID-19 pandemic. | Two years since COVID-19 outbreak. |
| Measure | Description | Time Frame |
|---|---|---|
| Further analysis on organ transplantation with stratification | Geographic disparities related to organ transplantation rates and association with COVID-19 clusters Living donor transplantation performed during the COVID-19 pandemic. Quality of transplanted organs (kidney) before and after the COVID-19 pandemic. Change in relationship between living donors and their recipients before and after the COVID-19 pandemic. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Solid organ transplants performed during the study period (kidney, lung, heart, liver and combined organs in Europe (France, Spain, Portugal, Germany, Italy, Croatia, Belgium, Netherlands, Austria), North America (US and Canada), Central and South America (Mexico, Brazil, Uruguay, Argentina and Chile) and Oceania (Australia)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alexandre Loupy | Contact | +33 1 53 98 80 00 | alexandre.loupy@inserm.fr |
| Name | Affiliation | Role |
|---|---|---|
| Alexandre Loupy | Paris Translational Research Center for Organ Transplantation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Paris Transplant Group | Recruiting | Paris | 75015 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32087115 | Background | Xu B, Kraemer MUG; Open COVID-19 Data Curation Group. Open access epidemiological data from the COVID-19 outbreak. Lancet Infect Dis. 2020 May;20(5):534. doi: 10.1016/S1473-3099(20)30119-5. Epub 2020 Feb 19. No abstract available. | |
| 32164834 | Background | Anderson RM, Heesterbeek H, Klinkenberg D, Hollingsworth TD. How will country-based mitigation measures influence the course of the COVID-19 epidemic? Lancet. 2020 Mar 21;395(10228):931-934. doi: 10.1016/S0140-6736(20)30567-5. Epub 2020 Mar 9. No abstract available. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
Not provided
Not provided
| UNKNOWN |
| Centro Nazionale Trapianti | UNKNOWN |
| Brazilian Organ Transplant Association | UNKNOWN |
| The Canadian Association of Transplantation | UNKNOWN |
| Scandiatransplant | UNKNOWN |
| Nederlandse Transplantatie Vereniging | UNKNOWN |
| Austrotransplant | UNKNOWN |
| Centro Nacional de Trasplantes | UNKNOWN |
| Instituto Nacional de Donación y Trasplante de Células, Tejidos y Órganos | UNKNOWN |
| Donor Network of Croatia | UNKNOWN |
| Instituto Nacional Central Único Coordinador de Ablación e Implante | OTHER_GOV |
| Corporación Nacional de Trasplantes de Chile | UNKNOWN |
| Australian Organ and Tissue Donation and Transplantation Authority | UNKNOWN |
| Organización Nacional de Trasplantes | UNKNOWN |
| Autoridade Para Services de Sangue e Transplantacáo | UNKNOWN |
Not provided
Not provided
Not provided
| Netherlands | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Austria | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| US | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Canada | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Mexico | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Brazil | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Uruguay | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Argentina | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Chile | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Australia | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Belgium | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Finland | All organs procured for transplantation and transplanted during the observation period. These include kidney, lung, liver, heart, and combined transplantations. |
| Two years since COVID-19 outbreak. |
| 32243281 | Background | Ahn C, Amer H, Anglicheau D, Ascher NL, Baan CC, Battsetset G, Bat-Ireedui B, Berney T, Betjes MGH, Bichu S, Birn H, Brennan D, Bromberg J, Caillard S, Cannon RM, Cantarovich M, Chan A, Chen ZS, Chapman JR, Cole EH, Cross N, Durand F, Egawa H, Emond JC, Farrero M, Friend PJ, Geissler EK, Ha J, Haberal MA, Henderson ML, Hesselink DA, Humar A, Jassem W, Jeong JC, Kaplan B, Kee T, Kim SJ, Kumar D, Legendre CM, Man K, Moulin B, Muller E, Munkhbat R, Od-Erdene L, Perrin P, Rela M, Tanabe K, Tedesco Silva H, Tinckam KT, Tullius SG, Wong G. Global Transplantation COVID Report March 2020. Transplantation. 2020 Oct;104(10):1974-1983. doi: 10.1097/TP.0000000000003258. No abstract available. |
| 32220200 | Background | Zhang X. Epidemiology of Covid-19. N Engl J Med. 2020 May 7;382(19):1869. doi: 10.1056/NEJMc2005157. Epub 2020 Mar 27. No abstract available. |
| 32305079 | Background | Martino F, Plebani M, Ronco C. Kidney transplant programmes during the COVID-19 pandemic. Lancet Respir Med. 2020 May;8(5):e39. doi: 10.1016/S2213-2600(20)30182-X. Epub 2020 Apr 16. No abstract available. |
| 32329975 | Background | Akalin E, Azzi Y, Bartash R, Seethamraju H, Parides M, Hemmige V, Ross M, Forest S, Goldstein YD, Ajaimy M, Liriano-Ward L, Pynadath C, Loarte-Campos P, Nandigam PB, Graham J, Le M, Rocca J, Kinkhabwala M. Covid-19 and Kidney Transplantation. N Engl J Med. 2020 Jun 18;382(25):2475-2477. doi: 10.1056/NEJMc2011117. Epub 2020 Apr 24. No abstract available. |
| 32354635 | Background | Coates PT, Wong G, Drueke T, Rovin B, Ronco P; Associate Editors, for the Entire Editorial Team. Early experience with COVID-19 in kidney transplantation. Kidney Int. 2020 Jun;97(6):1074-1075. doi: 10.1016/j.kint.2020.04.001. Epub 2020 Apr 9. No abstract available. |
| 32181795 | Background | Livingston E, Bucher K. Coronavirus Disease 2019 (COVID-19) in Italy. JAMA. 2020 Apr 14;323(14):1335. doi: 10.1001/jama.2020.4344. No abstract available. |
| 32250388 | Background | Omer SB, Malani P, Del Rio C. The COVID-19 Pandemic in the US: A Clinical Update. JAMA. 2020 May 12;323(18):1767-1768. doi: 10.1001/jama.2020.5788. No abstract available. |
| 32087114 | Background | Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020 May;20(5):533-534. doi: 10.1016/S1473-3099(20)30120-1. Epub 2020 Feb 19. No abstract available. |
| 28434650 | Result | Levin A, Tonelli M, Bonventre J, Coresh J, Donner JA, Fogo AB, Fox CS, Gansevoort RT, Heerspink HJL, Jardine M, Kasiske B, Kottgen A, Kretzler M, Levey AS, Luyckx VA, Mehta R, Moe O, Obrador G, Pannu N, Parikh CR, Perkovic V, Pollock C, Stenvinkel P, Tuttle KR, Wheeler DC, Eckardt KU; ISN Global Kidney Health Summit participants. Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. Lancet. 2017 Oct 21;390(10105):1888-1917. doi: 10.1016/S0140-6736(17)30788-2. Epub 2017 Apr 20. |
| 34474014 | Derived | Aubert O, Yoo D, Zielinski D, Cozzi E, Cardillo M, Durr M, Dominguez-Gil B, Coll E, Da Silva MI, Sallinen V, Lemstrom K, Midtvedt K, Ulloa C, Immer F, Weissenbacher A, Vallant N, Basic-Jukic N, Tanabe K, Papatheodoridis G, Menoudakou G, Torres M, Soratti C, Hansen Krogh D, Lefaucheur C, Ferreira G, Silva HT Jr, Hartell D, Forsythe J, Mumford L, Reese PP, Kerbaul F, Jacquelinet C, Vogelaar S, Papalois V, Loupy A. COVID-19 pandemic and worldwide organ transplantation: a population-based study. Lancet Public Health. 2021 Oct;6(10):e709-e719. doi: 10.1016/S2468-2667(21)00200-0. Epub 2021 Aug 30. |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |