Effect of Paracetamol and Ibuprofen Reducing Morphine Requirements After Total Knee Arthroplasty

Effect of Paracetamol and Ibuprofen When Intravenously Given Combination or Alone in Reducing Morphine Requirements After Total Knee Arthroplasty

Adequate pain management has an important role in supporting early ambulation after the Total Knee Arthroplasty (TKA). Multimodal analgesia is one of the modalities of overcoming postoperative pain. The use of combination Paracetamol and Ibuprofen injection is expected to reduce total morphine consumption after TKA.

The research will compare the effect of paracetamol injection and ibuprofen injection when given alone or in combination to reduce morphine requirement in a patient after total knee arthroplasty

Inclusion Criteria:

• Adult patient with 20 < BMI < 30 kg/m2
• Adult patient with knee varus alignment 10-20°

Exclusion Criteria:

• Impaired cardiac, liver, and/or renal function.
• History of substance abuse or chronic pain.
• Patients are known to be hypersensitive to any of the components of IV ibuprofen or IV paracetamol.
• Patients currently on anticoagulation medications.
• Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by an Institutional Review Board) and agree to abide by the study restrictions.