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Whether the perceived changes in management of Acute Severe Ulcerative Colitis during the COVID pandemic are widespread, and whether they have any impact on patient outcomes
The study aims to evaluate the process, evaluation and therapy variation in management of ASUC with reference to 2019 British Society of Gastroenterology guidelines and see whether there are any differences between ambulatory and hospital management in ASUC. Also to evaluate the outcomes in ASUC patients managed during the COVID-19 pandemic
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Main group | Patient with Acute Severe Ulcerative Colitis based on Modified Truelove and Witts Severity Index managed during the study period | ||
| Control Group | Patients with ASUC managed in the unit from 1st Jan to 31st June 2019 |
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| Measure | Description | Time Frame |
|---|---|---|
| Primary outcome measure: The need for in-hospital colectomy or rescue therapy | The need for in-hospital colectomy or rescue therapy | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| 2.1: Duration and type/route of steroid use | Duration and type/route of steroid use | 3 months |
| 2.2: 30 day colectomy free survival rates | 30 day colectomy free survival rates |
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Inclusion Criteria:
Exclusion Criteria:
Patients aged 16 -100 inclusive
Acute Severe Ulcerative Colitis based on Modified Truelove and Witts Severity Index managed during the study period
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In The UK alone approximately 6500 patients are admitted with ASUC each year
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| Name | Affiliation | Role |
|---|---|---|
| Shaji Sebastian | Hull University Teaching Hospitals | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gastroenterology, Hull Royal Infirmary, Hull University Teaaching Hospitals NHS Trust | Hull | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35101886 | Derived | Sebastian S, Patel KV, Segal JP, Subramanian S, Conley TE, Gonzalez HA, Kent AJ, Saifuddin A, Hicks L, Mehta S, Bhala N, Brookes MJ, Lamb CA, Kennedy NA; PROTECT ASUC collaborators; Walker GJ. Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study. BMJ Open Gastroenterol. 2022 Jan;9(1):e000763. doi: 10.1136/bmjgast-2021-000763. | |
| 33545083 |
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| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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| 3 months |
| 2.3: Covid-19 infection rates | Covid-19 infection rates | 3 months |
| 2.4: Rate of Rescue therapy use | Rate of Rescue therapy use | 3 months |
| 2.5: Duration of hospital stay | Duration of hospital stay | 3 months |
| 2.6: Admission severity scoring | Admission severity scoring | 3 months |
| 2.7: Readmission rates | Readmission rates | 3 months |
| Derived |
| Sebastian S, Walker GJ, Kennedy NA, Conley TE, Patel KV, Subramanian S, Kent AJ, Segal JP, Brookes MJ, Bhala N, Gonzalez HA, Hicks LC, Mehta SJ, Lamb CA; PROTECT-ASUC Study Group. Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study. Lancet Gastroenterol Hepatol. 2021 Apr;6(4):271-281. doi: 10.1016/S2468-1253(21)00016-9. Epub 2021 Feb 2. |