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Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes of the brain, the autonomic nervous system and pain processing systems.
Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes in the functional connectivity, spectroscopy, iron deposition and perfusion of the brain. In addition, we plan to investigate circadian changes in the pain threshold of the brain using quantitative sensory testing (QST). Finally, we will investigate changes in the autonomic nervous system measuring the pupillary response.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient group | Patients suffering from cluster headache will be included in this group. When analysing the data, the investigators will distinguish those in the in-bout period from those in the out-bout period. People in this group may participate twice: once in the in-bout and once in the out-bout period. |
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| Control group | Participants not suffering from cluster headache will be included in this group. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI examination | Diagnostic Test | Patient will be scanned in the MRI twice, once at noon (+/- 1 hour), once at 1 a.m. (+/- 1 hour). The investigators will search for any changes in functional connectivity, particular regarding the connection between the hypothalamus and pain-processing networks. |
| Measure | Description | Time Frame |
|---|---|---|
| Circadian rhythmicity of the functional connectivity of the brain | Changes from baseline in functional connectivity of the brain using whole-brain fMRI | Measurements will be made at noon and at 1 a.m. (+/- 2 hours); we will compare these measurements to identify changes. |
| Measure | Description | Time Frame |
|---|---|---|
| Circadian rhythmicity of the pain threshold | Changes from baseline of the pain threshold in the face using quantitative sensory testing (QST) | Measurements will be made at noon and at 1 a.m. (+/- 2 hours); we will compare these measurements to identify changes. |
| Circadian changes in the perfusion of the brain. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients suffering from cluster headache.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Heiko Pohl, MD | Contact | +41 44 255 1856 | heiko.pohl@usz.ch |
| Name | Affiliation | Role |
|---|---|---|
| Heiko Pohl, MD | University of Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital Zurich | Recruiting | Zurich | Canton of Zurich | 8091 | Switzerland |
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| ID | Term |
|---|---|
| D003027 | Cluster Headache |
| D051303 | Trigeminal Autonomic Cephalalgias |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Changes from baseline in perfusion of the brain using Arterial Spin Labeled MRI Perfusion Imaging and vascular space occupancy sequences |
| Measurements will be made at noon and at 1 a.m. (+/- 2 hours); we will compare these measurements to identify changes. |
| Circadian rhythmicity of the autonomic system | Changes from baseline in the pupillary response (measured using pupillometry) | Measurements will be made at noon and at 1 a.m. (+/- 2 hours); we will compare these measurements to identify changes. |
| Circadian rhythmicity of the spectroscopy of the hypothalamus | Changes from baseline in the spectroscopy of the hypothalamus | Measurements will be made at noon and at 1 a.m. (+/- 2 hours); we will compare these measurements to identify changes. |
| Circadian rhythmicity of the spectroscopy of the hypothalamus | Changes from baseline in the iron concentration of the brain using quantitative susceptibility mapping | Measurements will be made at noon and at 1 a.m. (+/- 2 hours); we will compare these measurements to identify changes. |
| D009422 | Nervous System Diseases |