Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache

Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache

Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes of the brain, the autonomic nervous system and pain processing systems.

Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes in the functional connectivity, spectroscopy, iron deposition and perfusion of the brain. In addition, we plan to investigate circadian changes in the pain threshold of the brain using quantitative sensory testing (QST). Finally, we will investigate changes in the autonomic nervous system measuring the pupillary response.

Inclusion Criteria:

• Diagnosis of cluster headache (CH) may enter the patient group, patients not suffering from CH may enter the control group.
• knowledge of the german language suffices to understand the information sheet and consent form
• having read, understood and signed the consent form

Exclusion Criteria:

• Pregnancy
• contraindications for the MRI scan (particularly metal splinters, ferromagnetic devices and implants)
• claustrophobia
• obesity (MRI > 35 kg/m2)
• shift working (last night shift must date back more than one week)
• jet lag (last travel over more than two time zones must date back more than one week)