fed a standardized meal

neuroimaging with computational modeling

Frontostriatal activation associated with successful inhibition , measured as the mean BOLD signal across voxels within the region of interest (ROI) for the contrast of Successful Stop vs. Go trials. Positive values indicate activation associated with successful inhibition.

Percent correct responses to stop trials on the Stop Signal Task measured by percent of stop trials on which participant successfully withheld a response (vs. failed to withhold response).

Total of all reporting groups

Eating Disorder Examination (EDE): Frequency of objective binge eating episodes - number of times the behavior occurred (past 28 days)

For healthy controls, EDE was administered to confirm healthy control status. Data not relevant in healthy controls, who by definition could not have any binge eating.

EDE: Frequency of self-induced vomiting episodes - number of times the behavior occurred (past 28 days).

For healthy controls, EDE was administered to confirm healthy control status. Data not relevant in healthy controls, who by definition could not have any purging behaviors.

EDE: Frequency of fasting episodes - number of times the behavior occurred (past 28 days)

For healthy controls, EDE was administered to confirm healthy control status. Data not relevant in healthy controls, who by definition could not have any fasting episodes.

Frontostriatal activation modulated by unsigned inhibitory control prediction errors (i.e., parametric modulation by absolute prediction error magnitude), measured as the mean BOLD signal across voxels within the region of interest (ROI). Positive values indicate that neural activation increases with the magnitude of unsigned prediction errors (i.e., stronger responses to more surprising outcomes), whereas negative values indicate that activation decreases as unsigned prediction errors increase (i.e., relative deactivation for more surprising outcomes).

Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.

Frontostriatal activation modulated by signed inhibitory control prediction errors (i.e., parametric modulation by prediction error magnitude), measured as the mean BOLD signal across voxels within the region of interest (ROI). Positive values indicate that neural activation increases as signed prediction errors become more positive (i.e., stronger responses to the surprising need for control), whereas negative values indicate that activation decreases as signed prediction errors become more positive (i.e., stronger responses to the surprising lack of need for control).

Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.

Frontostriatal activation associated with successful inhibition , measured as the mean BOLD signal across voxels within the region of interest (ROI) for the contrast of Successful Stop vs. Go trials. Positive values indicate activation associated with successful inhibition.

Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.

Behavioral performance on the stop signal task, as measured by stop signal reaction time calculated as mean go reaction time minus the stop-signal delay at 50% successful inhibition (SSD₅₀). Higher SSRT means longer latency before failed inhibition.

Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.

Percent correct responses to stop trials on the Stop Signal Task measured by percent of stop trials on which participant successfully withheld a response (vs. failed to withhold response).

Brain imaging data were pre-processed and analyzed for each group and state. Data from 8 participants were excluded: 2 HC due to technical malfunction that caused loss of behavioral data from their 2nd MRI visit, 1 HC for incidental finding on MRI (not identified until after their 2nd scan), 2 (1 BN, 1 HC) for insufficient trials for analysis in a key condition at one or both scans, and 3 BN for excessive movement (>20% of TRs with ≥0.5mm framewise displacement) at one or both scans.

Participants were scanned after 16 hours of fasting (Fasted Scan) on one day, and were scanned after a standardized meal on a separate day (Fed Scan). The order of these fasted and fed visits was counterbalanced across participants.

Incidental finding