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This is a single center observational study to assess alteration of glucose metabolism after pancreatectomy.
Biochemical markers of glucose metabolism including oral glucose tolerance tests, fasting blood glucose, insulin, glucagon and HbA1c were performed on patients receiving pancreatectomy (pancreaticoduodenectomy and distal pancreatectomy). Tests were done preoperatively, postoperatively at 3 months, and at 1 year. The primary endpoints were the incidence and risk factors of new-onset and worsened DM after each type of pancreatectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PD | pancreaticoduodenectomy |
| |
| DP | distal pancreatectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oral glucose tolerance test | Diagnostic Test |
|
| Measure | Description | Time Frame |
|---|---|---|
| incidence & risk factors of new-onset DM | incidence & risk factors of new onset DM after pancreatectomy | at 1 year |
| incidence & risk factors of worsened DM | incidence & risk factors of worsened DM after pancreatectomy | at 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| characteristics of new-onset and worsened DM | changes of glucose metabolism during study period | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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patients receiving partial pancreatectomy
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16324932 | Background | Lee BW, Kang HW, Heo JS, Choi SH, Kim SY, Min YK, Chung JH, Lee MK, Lee MS, Kim KW. Insulin secretory defect plays a major role in the development of diabetes in patients with distal pancreatectomy. Metabolism. 2006 Jan;55(1):135-41. doi: 10.1016/j.metabol.2005.08.005. | |
| 29390555 | Background | Hwang HK, Park J, Choi SH, Kang CM, Lee WJ. Predicting new-onset diabetes after minimally invasive subtotal distal pancreatectomy in benign and borderline malignant lesions of the pancreas. Medicine (Baltimore). 2017 Dec;96(51):e9404. doi: 10.1097/MD.0000000000009404. |
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There are no plans of sharing IPD
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| ID | Term |
|---|---|
| D006943 | Hyperglycemia |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |