Stress Hyperglycemia and Acute Ischemic Stroke

Stress Hyperglycemia as a Prognostic Factor in Acute Ischemic Stroke Patients

Whereas diabetes mellitus is clearly a risk factor for the occurrence of stroke and for its poor prognosis, hyperglycemia per se is also linked to increased morbidity and mortality in stroke patients.Therefore, the objective of this work was to study the glycemic status of acute ischemic stroke patients and to assess its impact on stroke outcome.

Using PASS program, setting alpha error at 5% and power of 80%, the total sample size was estimated to be 80 cases.

The NIHSS was used as a primary outcome; 40 cases were needed in each group. Secondary outcomes were hemorrhagic transformation, hospital stay duration, mechanical ventilation, need for vasopressors, and 30-days mortality.

Inclusion Criteria:

• Acute ischemic stroke within 24 hours of onset of symptoms

Exclusion Criteria:

• subdural hematoma
• Transient ischemic attack
• Subarachnoid hemorrhage
• Hemorrhagic stroke
• Major comorbidities Hyperglycemia on admission that was controlled (random blood sugar (RBS) < 150 mg/dl) within 24 hours with insulin therapy, diabetic
• Ketoacidosis
• RBS less than 70 mg/dl on admission