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This study examines the seroprevalence against SARS-CoV-2 in health care workers and patients at the Vienna General Hospital.
This study consists of 2 parts: a longitudinal study enrolling 3,000 health care professionals at the Vienna General Hospital testing their antibody status 6 times over a period of 12 months (Cohort A), and a serial cross-sectional study of 3,000 patients (i.e., a total of 9,000 patients) admitted to the Vienna General Hospital for non-COVID-19-related symptoms at 3 different time points during this pandemic (Cohort B).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Health care workers | Physicians, Nursing staff, Midwives, Medical-technical assistants (including medical, therapeutic and diagnostic healthcare staff, and medical and nursing assistants), administrative personnel with patient contact |
| |
| Patients | Patients admitted for non-COVID related symptoms to the Vienna General Hospital with available residual serum samples. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laboratory Analyses | Diagnostic Test | Storage of serum for SARS-CoV-2-antibodies and biomarkers |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of antibody status in healthcare workers and in patients admitted for non-COVID-19 related symptoms over time | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence rate of sero-conversion | 1 year | |
| Identification of risk markers/factors for SARS-CoV-2 infection | 1 year |
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Cohort A:
Inclusion criteria:
Exclusion Criteria:
Cohort B:
Inclusion Criteria:
● Patients with available residual serum samples
Exclusion Criteria:
● Serum samples from COVID-19 triage units at the Vienna General Hospital
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Cohort A: Health care workers
Cohort B: Patients admitted for non-COVID related symptoms
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christian Hengstenberg, Univ.-Prof. | Contact | +43 1 40400 | 46140 | christian.hengstenberg@meduniwien.ac.at |
| Thomas A Zelniker, DDr. | Contact | +43 1 40400 | 46140 | thomas.zelniker@meduniwien.ac.at |
| Name | Affiliation | Role |
|---|---|---|
| Christian Hengstenberg, Univ.-Prof. | Medical University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Recruiting | Vienna | 1090 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36657754 | Derived | Riesenhuber M, Nitsche C, Binder CJ, Schernhammer ES, Stamm T, Jakse F, Anwari E, Hamidi F, Haslacher H, Perkmann T, Hengstenberg C, Zelniker TA. Comparison of the prevalence of SARS-CoV-2 nucleoprotein antibodies in healthcare workers and an unselected adult and paediatric all-comer patient population: insights from a longitudinal study of healthcare workers and concurrent serial cross-sectional studies of patients at an academic medical centre in Austria. BMJ Open. 2023 Jan 18;13(1):e063760. doi: 10.1136/bmjopen-2022-063760. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D014777 | Virus Diseases |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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Serum samples
| D018352 |
| Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |