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| Name | Class |
|---|---|
| Wolfson Medical Center | OTHER_GOV |
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Low serum L-arginine (Arg) and high asymmetric dimethylarginine (ADMA) can predict microvascular complications in type 2 diabetes (T2DM). The investigators examined whether or not Arg and ADMA are affected by dietary factors or lifestyle modification in overweight/ obese and T2DM subjects.
The investigators tested the effects on serum Arg and ADMA of a) a single load of ingested dextrose, protein, fat or alcohol, each consumed within 10 minutes; b) a single episode of physical exercise; c) a 12 weeks lifestyle modification program comprised of a standard dietary and physical activity counseling in obese or T2DM subjects on circulating Arg and ADMA (n=43)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute glucose tolerance test | Experimental | A standard oral glucose tolerance test (75 grams of dextrose in 180 cc of water) |
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| Acute protein load test | Experimental | A protein-rich, vanilla-flavored powder (Pro-gym, Telpharma, Is |
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| Acute fat load test | Experimental | a 100-gram portion of sweet cream containing 300 Kacls, of which 94% of the ingested calories were fat |
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| Acute alcohol load test | Experimental | Vodka (100 cc, 40% alcohol) |
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| Acute exercise | Experimental | 30 minutes of supervised graded walking on a treadmill according to each subject's individual ability. A goal heart rate was calculated as 70% of the age-adjusted maximal allowable heart rate. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acute dietary protocols and lifestyle modification | Behavioral | The investigators tested the effects on serum Arg and ADMA of a) a single load of ingested dextrose, protein, fat or alcohol, each consumed within 10 minutes; b) a single episode of physical exercise; c) a 12 weeks lifestyle modification program comprised of a standard dietary and physical activity counseling in obese or T2DM subjects on circulating Arg and ADMA (n=43). |
| Measure | Description | Time Frame |
|---|---|---|
| Serum L-arginine change | Change in arginine levels (absolute and relative) (µmol/l) | For acute phase: before the nutritional/exercise load (time 0), as well as 30, 60, 90, 120 and 150 minutes after the challenge test. And from baseline to 12 weeks for lifestyle modification phase |
| High asymmetric dimethylarginine (ADMA) change | Change in ADMA levels (absolute and relative) (µmol/l) | For acute phase: before the nutritional/exercise load (time 0), as well as 30, 60, 90, 120 and 150 minutes after the challenge test. And from baseline to 12 weeks for lifestyle modification phase |
| Measure | Description | Time Frame |
|---|---|---|
| Body mass index (BMI) change | Change in BMI levels (Kg/m2) | From baseline to 12 weeks for lifestyle modification phase |
| Glycated hemoglobin (HbA1c) change | Change in HbA1c levels (%) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Naftali Stern, MD | Tel-Aviv Sourasky Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Diabetes Unit, E. Wolfson Medical Center | Holon | 5822012 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35708634 | Derived | Buch A, Ganz T, Wainstein J, Gilad S, Limor R, Shefer G, Boaz M, Stern N. Alcohol Drinks Induce Acute Lowering in Circulating l-Arginine in Obese and Type 2 Diabetic Subjects. J Med Food. 2022 Jun;25(6):675-682. doi: 10.1089/jmf.2021.0045. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Lifestyle modification program - 12 weeks | Experimental | 12 weeks of weight-loss dietary program constructed according to the guidelines of the American Diabetes Association. Based on weight, gender, and age, daily dietary allowance varied at 1200-1800 Kcal, 50% carbohydrates, 20% protein, and 30% fat. Participants were also asked to engage in moderate physical activity comprised of a 40-minute walk three times a week. A weekly clinic visit alternating with a weekly telephone contact was also required. |
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| From baseline to 12 weeks for lifestyle modification phase |
| D004700 | Endocrine System Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |