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The purpose of the study is to describe the incidence of complications in brain death adult organ donors.
Pathophysiological changes following brain death may complicate the care of brain death donors. These complications negatively affects function of donated organs. Understanding these complications and its incidence is crucial for their appropriate management. The aim of this retrospective observational study is to evaluate the incidence of complications in adult brain death organ donors. Date will be collected from medical records of eligible patients admitted to intensive care unit for suspected brain death in whom brain death was confirmed and who become organ donors.
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| Measure | Description | Time Frame |
|---|---|---|
| Hypotension | Hypotension is defined as increase of vasoactive drug dose by 20% or systolic blood pressure lower than 90 mmHg or need for fluid resuscitation after initial normovolemia was achieved | 48hours prior confirmation of brain death to ICU discharge |
| Serum lactate level | Maximal lactate level will be evaluated during ICU stay | 48hours prior confirmation of brain death to ICU discharge |
| Catecholamine storm | Catecholamine storm is defined as onset of tachycardia and/or hypertension | 48hours prior confirmation of brain death to ICU discharge |
| Myocardial dysfunction | Myocardial dysfunction is defined as left ventricle ejection fraction under 50% on trans-thoracic echocardiography or S-T segment depression or elevation or T wave negativity or positive troponin serum level | 48hours prior confirmation of brain death to ICU discharge |
| ARDS | ARDS is defined and stratified according to Berlin definition | 48hours prior confirmation of brain death to ICU discharge |
| Oxygenation index | Oxygenation index will be calculated as PaO2 divided by FiO2 | 48hours prior confirmation of brain death to ICU discharge |
| Diabetes insipidus | Diabetes insipidus is defines as urine output more than 4ml/kg per hour or urine specific gravity under 1010 |
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Inclusion Criteria:
Exclusion Criteria:
- age under 18 years
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Adult critically ill patinets with confirmed brain death admitted to university hospital who become brain death organ donor.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ondrej Hrdy, MD | Contact | 532233850 | +420 | hrdy.ondrej@fnbrno.cz |
| Viktor Agalarev, MD | Contact | 532233850 | +420 | agalarev.viktor@fnbrno.cz |
| Name | Affiliation | Role |
|---|---|---|
| Roman Gal, MD, PhD | Brno University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Brno | Recruiting | Brno | 62500 | Czechia |
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| ID | Term |
|---|---|
| D001926 | Brain Death |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D003128 | Coma |
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| 48hours prior confirmation of brain death to ICU discharge |
| Renal dysfunction | Renal dysfunction is defined as presence of at least one of these criteria: absolute increase in serum creatinine ≥0.3 mg/dL (≥26.4 μmol/L) or increase in serum creatinine ≥1.5x above baseline or oliguria (urine output <0.5 mL/kg per hour) for >6 hours | 48hours prior confirmation of brain death to ICU discharge |
| Coagulopathy | Coagulopathy is defined as international normalised ratio above 1,5 or platelet count below 100 000 per microliter | 48hours prior confirmation of brain death to ICU discharge |
| Hypothermia | Body temperature below 36°C or need for external warming | 48hours prior confirmation of brain death to ICU discharge |
| D014474 |
| Unconsciousness |
| D003244 | Consciousness Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D003643 | Death |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |