To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.

A rheumatology biorepository will be created to permit comparative analyses between the rheumatic diseases in order to increase the understanding of disease pathogenesis. Patients seen at Yale clinics diagnosed with rheumatic diseases are invited to participate in this study. These rheumatic diseases include, but are not limited to: adult onset Still's disease, ankylosing spondylitis, psoriatic arthritis, reactive arthritis, antiphospholipid syndrome, systemic lupus erythematosus, Behcet's disease, dermatomyositis, polymyositis, giant cell arteritis and other vasculitides, Lyme's disease, mixed connective tissue disease, polymyalgia rheumatica, rheumatoid arthritis, sarcoidosis, systemic sclerosis (scleroderma), Sjogren's syndrome, and undifferentiated connective tissue disease.

Inclusion Criteria for Rheumatology Patients:

• Patients ≥18 years old with a diagnosis of a rheumatic autoimmune disease including, but not limited to: adult onset Still's disease, ankylosing spondylitis, antiphospholipid syndrome, Behcet's disease, dermatomyositis, giant cell arteritis, mixed connective tissue disease, polymyalgia rheumatica, polymyositis, psoriatic arthritis, reactive arthritis, rheumatoid arthritis, sarcoidosis, scleroderma, Sjogren's syndrome, systemic lupus erythematosus, undifferentiated connective tissue disease and vasculitis.
• Receiving clinical care at Yale Rheumatology clinics

Exclusion Criteria for Rheumatology Patients:

• Unable to provide informed consent
• No patients will be excluded based on gender or ethnicity or pregnancy status.
• Women who are currently pregnant will need to wait to donate a skin biopsy until after they deliver.
• Patients allergic to lidocaine or epinephrine or have a history of impaired wound healing will not be able to donate a skin biopsy.

Inclusion Criteria for Healthy Volunteers:

• Age ≥ 18 years old
• No chronic skin conditions
• No diagnosis of a rheumatic autoimmune disease (e.g., lupus, rheumatoid arthritis)
• Normal BMI

Exclusion Criteria for Healthy Volunteers:

• Unable to provide informed consent.
• Currently pregnant or nursing unless the study goal is to study pregnant or nursing woman.
• Allergies to lidocaine or epinephrine (skin biopsies).
• A history of impaired wound healing (skin biopsies).

The biorepository will consist of both new and established patients with a rheumatic autoimmune disease diagnosis who visit a Yale Rheumatology medical facility and agree to participate in this study. The biorepository will also consist of healthy volunteers who agree to participate in this study.

No plan at this time.