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To evaluate possibilities of rapid differential diagnosis and risk stratification in patients urgently admitted to the CCU with a suspected acute coronary syndrome without persistent ST-segment elevation (NSTEACS).
Single centre prospective non-randomised non-comparative study of patients delivered by ambulance and admitted to the CCU with suspected NSTEACS.
Aims of this study are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Suspected NSTEACS | Patients urgently admitted to the CCU with suspected NSTEACS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Approaches to differential diagnosis and risk stratification | Diagnostic Test | Detailed analysis of clinical course, ECG, biomarkers (hsTn I, CK-MB mass, myoglobin, NT-proBNP, hsCPR, cardiac FABP on admission and after 3 hours; hsTn I, CK-MB mass and myoglobin after 6 hours if needed) as well as HEART, ADAPT, EDACS, T-MACS, GRACE, ACTION and TIMI scores. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical outcomes | Composite of death, (re) infarction, stroke or re-hospitalization | 6 monts |
| Final diagnosis | Final diagnosis - the main reason for urgent hospitalization - according to hospital case history | Up to 1 monts |
| Measure | Description | Time Frame |
|---|---|---|
| Death | Death upon discharge and up to 6 months | 6 months. |
| (re) infarction | (re) infarction upon discharge and up to 6 months | Up to 1 monts |
| Measure | Description | Time Frame |
|---|---|---|
| Urgent revascularisation | Revascularisation performed due to sudden clinical deterioration | Up to 1 monts |
| Other adverse events | All adverse events/complications not included in clinical outcomes end points. |
Inclusion Criteria:
Exclusion Criteria:
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Patients delivered by ambulance and admitted to the CCU with suspected diagnosis "acute coronary syndrome (ACS)".
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| Name | Affiliation | Role |
|---|---|---|
| Igor S Yavelov, PhD | National Medical Research Center for Therapy and Preventive Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Eramishantsev Hospital | Moscow | Russia |
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| ID | Term |
|---|---|
| D004194 | Disease |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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hsTn, NT-proBNP, hsCPR, cardiac FABP
|
| Stroke | Stroke upon discharge and up to 6 months | 6 months. |
| Re-hospitalization | Recurrent hospital admissions after discharge form the index hospitalization | 6 months. |
| 6 months. |