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| Name | Class |
|---|---|
| Hallym University | OTHER |
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Suprascapular nerve block (SSNB) is most commonly used for relieving postoperative pain of arthroscopic rotator cuff repair and it can be used in combination with axillary nerve block (ANB). Dexmedetomidine (DEX) is known as a type of alpha agonist which can elongate the duration of regional block. The aim of this study was to compare the results of dexmedetomidine combined with SSNB and ANB with SSNB and ANB alone on postoperative pain, satisfaction, and pain-related cytokines within the first 48 hours after arthroscopic rotator cuff repair.
Forty patients with rotator cuff tears who had undergone arthroscopic rotator cuff repair were enrolled in this single center, double-blinded randomized controlled trial study. Twenty patients were randomly allocated to group 1 and received ultrasound-guided SSNB and ANB using each mixture of 0.5 ml (50 μg) of DEX and 9.5 ml of 0.75% ropivacaine preemptively. The other 20 patients were allocated to group 2 and underwent ultrasound-guided SSNB and ANB alone using a mixture of 0.5 ml of normal saline and 9.5 ml of ropivacaine. The visual analog scale (VAS) for pain and patient satisfaction (SAT) scores were checked within 48 h postoperatively. The plasma interleukin (IL)-6, -8,-1β, cortisol, and serotonin levels were also measured within 48 h postoperatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SSNB and ANB c DEX | Experimental | We used 9.5 ml of 0.75% ropivacaine and 0.5 ml (50 μg) of dexmedetomidine each for SSNB and ANB. |
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| SSNB and ANB c saline | Placebo Comparator | We used 9.5 ml of 0.75% ropivacaine and 0.5 ml normal saline each for SSNB and ANB. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine injection | Drug | We used 9.5 ml of 0.75% ropivacaine and 0.5 ml (50 μg) of dexmedetomidine each for preemptive suprascapular nerve block and axillary nerve block just before arthroscopic repair of rotator cuff tear. |
| Measure | Description | Time Frame |
|---|---|---|
| visual analog scale of pain | The VAS pain score was based on a scale from 0 to 10, where 0 indicated no pain and 10 indicated severe pain. | change from baseline VAS pain score at hour 48 |
| Measure | Description | Time Frame |
|---|---|---|
| patient's satisfaction | patient's satisfaction score was based on a scale from 0 to 10, where 0 indicated no satisfaction and 10 indicated much satisfaction. | change from baseline patient's satisfaction score at hour 48 |
| Plasma cortisol level |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jung-Taek Hwang, MD, PhD | Chuncheon Sacred Heart Hospital, Hallym University Medical College | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chuncheon Sacred Heart Hospital | Chuncheon | Gangwon-do | 24253 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32975624 | Derived | Lee JJ, Kim DY, Hwang JT, Song DK, Lee HN, Jang JS, Lee SS, Hwang SM, Moon SH, Shim JH. Dexmedetomidine combined with suprascapular nerve block and axillary nerve block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair. Knee Surg Sports Traumatol Arthrosc. 2021 Dec;29(12):4022-4031. doi: 10.1007/s00167-020-06288-8. Epub 2020 Sep 25. |
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We will discuss it with our IRB.
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|
| Saline injection | Drug | We used 9.5 ml of 0.75% ropivacaine and 0.5 ml normal saline each for preemptive suprascapular nerve block and axillary nerve block just before arthroscopic repair of rotator cuff tear. |
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A 3-ml blood sample was retrieved from the peripheral vein of the contralateral upper limb or both lower limbs per sampling.
| change from baseline plasma cortisol level at hour 48 |
| Plasma IL-6 level | A 3-ml blood sample was retrieved from the peripheral vein of the contralateral upper limb or both lower limbs per sampling. | change from baseline plasma IL-6 level at hour 48 |
| Plasma IL-8 level | A 3-ml blood sample was retrieved from the peripheral vein of the contralateral upper limb or both lower limbs per sampling. | change from baseline plasma IL-8 level at hour 48 |
| Plasma IL-1β level | A 3-ml blood sample was retrieved from the peripheral vein of the contralateral upper limb or both lower limbs per sampling. | change from baseline plasma IL-1β level at hour 48 |
| Plasma serotonin level | A 3-ml blood sample was retrieved from the peripheral vein of the contralateral upper limb or both lower limbs per sampling. | change from baseline plasma serotonin level at hour 48 |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
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