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This study will compare the outcome of partial pulpotomy and complete pulpotomy in mature permanent molars with clinical signs indicative of irreversible pulpitis
After thorough history and clinical and radio graphic examination, and confirmation of eligibility for the study, written informed consent will be taken after explaining the procedure and its associated risks and benefits. Clinical diagnosis of irreversible pulpitis will be established based on a history of spontaneous pain or pain exacerbated by cold stimuli and lasting for a few seconds to several hours (lingering pain) compared to control teeth and which is reproducible using cold testing. Once included, study subjects will be randomly allocated to either Complete Pulpotomy group or Partial Pulpotomy group. (Mineral Trioxide Aggregate) MTA will be used as pulpotomy agent. A layer of resin modified Glass Ionomer liner will be placed over the MTA and tooth will be permanently restored with composite resin in second appointment.
Pain analysis will be carried out preoperatively and postoperatively at every 24 hours till 7 days after intervention. All the subjects will be followed up for evaluation of success at every 3 months from baseline to 1 year.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Complete Pulpotomy | Active Comparator | In case of complete pulpotomy procedure the exposed pulp tissue will be amputated using sterile bur in high speed hand piece to the level of canal orifices. |
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| Partial Pulpotomy | Active Comparator | In case of partial pulpotomy procedure the exposed pulp tissue will be amputated using a sterile bur in the high speed hand piece to a depth of 2-3 mm. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pulpotomy to the level of canal orifices | Procedure | Pulp tissue will be removed till the level of canal orifices. |
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| Measure | Description | Time Frame |
|---|---|---|
| Clinical Success and radiographic success | CLINICAL SUCCESS CRITERIA: Absence of spontaneous pain, discomfort, swelling, sinus tract or tenderness to palpation or percussion. RADIOGRAPHIC SUCCESS CRITERIA: No pathosis evident on the radiograph such as root resorption, furcal pathosis or new periapical pathosis. Periapical Index score 1 or 2 according to Orstavic et al. Evaluation of both clinical and radiographic outcome is must for analyzing the actual success of therapeutic technique. Number of participants fulfilling both clinical as well as radiographic success criteria will be considered in success category. | Baseline to 12 Months |
| Measure | Description | Time Frame |
|---|---|---|
| Pain analysis | To assess incidence and intensity of pain postoperatively at every 24 hours till 7 days using Visual analogue Scale of 0 to 10 Centimetere line. Score 0 means no pain and Score 10 means maximum pain. | Baseline to 7 days |
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Inclusion Criteria: Inclusion criteria
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| ANKITA RAMANI | POST GRADUATE INSTITUTE OF DENTAL SCIENCES, ROHTAK | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ankita Ramani | Rohtak | Haryana | 124001 | India |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40898413 | Derived | Ramani A, Sangwan P. Outcome Following Complete and Partial Pulpotomy in Managing Cariously Exposed Mature Permanent Molars With Symptomatic Irreversible Pulpitis: A 5-Year Follow-Up of a Randomised Clinical Trial. Int Endod J. 2025 Dec;58(12):1835-1848. doi: 10.1111/iej.70028. Epub 2025 Sep 2. | |
| 35226769 | Derived |
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| Pulpotomy up to superficial 2-3 mm of pulp chamber | Procedure | Only superficial pulp from the chamber will be removed |
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| Ramani A, Sangwan P, Tewari S, Duhan J, Mittal S, Kumar V. Comparative evaluation of complete and partial pulpotomy in mature permanent teeth with symptomatic irreversible pulpitis: A randomized clinical trial. Int Endod J. 2022 May;55(5):430-440. doi: 10.1111/iej.13714. Epub 2022 Mar 10. |