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In patients treated for exudative age-related macular degeneration (AMD), diabetes, retinal venous occlusion (OVR), or other conditions causing macular edema, treatments with anti-angiogenic intravitreal injections (IVT) are widely used both for their anti-angiogenic action. Patients often have injections for many years, sometimes monthly or every 2 months.
The discontinuation of treatment with repeated injections of anti-angiogenic agents, linked to the COVID-19 coronavirus pandemic will potentially impact the visual acuity, the ophthalmological state and the quality of life of the patients concerned, therefore it is relevant to analyze the consequences the breakdown of usual care in this population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients treated with IVT before COVID19 pandemia | Treatment started at least 6 months before the French confinement for COVID19 (15th march 2020) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Questionnaire | Procedure | At inclusion : Questionnaire collecting data concerning the interruption of IVT treatment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of visual acuity in patients treated with repeated IVT anti-angiogens during the COVID-19 epidemic | Change from baseline (last visual acuity before confinement) and visual acuity 6 months after resumption of follow-up | Baseline (Before confinement) and 6 months after resumption of follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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Patients treated with repeated IVT treatment of anti-angiogenic drugs
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| Name | Affiliation | Role |
|---|---|---|
| Martine MAUGET FAYSSE, MD | Fondation Adolphe de Rothschild | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Pôle Vision du val d'Ouest | Écully | France | ||||
| Fondation Adolphe de Rothschild |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37024478 | Derived | Sukkarieh G, Bonnin S, Azar G, Lafolie J, Alonso AS, Erol O, Pineau J, Villain H, Guillaume J, Auge E, Mingou A, Lejoyeux R, Vasseur V, Mauget-Faysse M. Outcome of Patients Treated by Intravitreal Injections During the COVID-19 Lockdown: An Institutional Experience. Curr Eye Res. 2023 Jul;48(7):683-689. doi: 10.1080/02713683.2023.2200564. Epub 2023 Apr 12. |
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| Data collection up to 1 year | Other | Data collection up to 1 year after resumption of follow-up: visual acuity, OCT : optical coherence tomography, IVT treatment, complications |
|
| Paris |
| 75019 |
| France |
| Hôpital Lariboisière | Paris | France |
| Centre ophtalmologique Maison Rouge | Strasbourg | France |
| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| D012170 | Retinal Vein Occlusion |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
| D020246 | Venous Thrombosis |
| D013927 | Thrombosis |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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