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The reduction in alveolar bone dimensions is an inevitable outcome after tooth extraction due to the healing events that results in bone modeling/remodeling. Alveolar ridge preservation is a successful approach that aids in reducing these changes greatly. Various techniques have been employed to achieve that outcome utilizing bone grafts and/or membrane. Dentin graft is a promising type that can overcome many of the limitations facing mainstream grafts. Autogenous source serve the advantage of providing graft with no cross-infection risk or immunogenicity. Moreover, the unique structure of dentin makes it suitable for osteoinduction and osteoconduction that yields favorite bone regeneration outcomes. Demineralization of dentin is essential to release trapped growth factors, expose collagen fibrils and enhance the grafts degradability and replacement by native tissues. Many acids have been investigated for the use in chairside preparation of the dentin graft and hence, clinicians are faced with different choices but little evidence regarding the acid which yield s better outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| autogenous dentin graft treated with nitric acid | Experimental |
| |
| autogenous dentin graft treated with hydrochloric acid | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alveolar ridge preservation after extraction | Procedure | atraumatic extraction followed by graft material insertion |
|
| Measure | Description | Time Frame |
|---|---|---|
| Radiographic bone changes | width and height losses (quantitative in mm) | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| histological analysis | Histologic observations (qualitative) and histomorphometric measurements (quantitative in %) | 6 months |
| soft tissue healing | rate of wound epitheliallization |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D016301 | Alveolar Bone Loss |
| ID | Term |
|---|---|
| D001862 | Bone Resorption |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D055093 | Periodontal Atrophy |
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Split-mouth prospective randomized clinical trial with 1:1 assignment
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| Biweekly for 6 weeks |
| D010510 |
| Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |