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Clinical evaluation of a new educative tools (Smartphone application) based on impact of instrumental dead space reduction after initiation of protective ventilation during mechanical ventilation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Protective ventilation with HME | Other | Protective ventilation + HME |
|
| Protective ventilation with Heated humidifier | Other | Protective ventilation + HH |
|
| Implementation of protective ventilation | Other | Protective ventilation implementation |
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| Tidal Volume reduction | Other | Tidal volume reduction |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protective ventilation implementation | Procedure | In this condition, we will implement the protective ventilation related with gender and height . A blood gas will be performed at before protective ventilation implementation and at the end of this condition.Time condition 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| PaCO2 Variation | The primary outcome is to evaluate the PaCO2 variation at the end of condition 2 (after 30 minutes with protective ventilation+ HME) and condition 4 (30 minutes after Tidal volume reduction + Heater humidifier). Variation <= 10% of PaCO2 | 60 minutes post intervention |
| PaCO2 Variation | The primary outcome is to evaluate the PaCO2 variation at the end of condition 2 (after 30 minutes with protective ventilation+ HME) and condition 4 (30 minutes after Tidal volume reduction + Heater humidifier). Variation <= 10% of PaCO2 | 120 minutes post intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between PCO2 variation and alveolar ventilation variation | We will compare PaCO2 level variation and the alveolar ventilation variation to establish correlation. Correlation variation under 10% will be significative | 60 and 90 minutes post intervention |
| Hemodynamic impact vs pH |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| François Lellouche | Contact | 1-418-656-8711 | Francois.Lellouche@criucpq.ulaval.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval | Recruiting | Québec | G1V4G5 | Canada |
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| Protective ventilation with HME | Procedure | In this condition, the patient will received protective ventilation with a Heat Moisture Exchanger (HME). A blood gas will be performed at the end of this condition.Time condition 30 minutes |
|
| Protective ventilation with Heated humidifier | Procedure | In this condition, the patient will received protective ventilation with a Heated humidifier. A blood gas will be performed at the end of this condition.Time condition 30 minutes |
|
| Tidal Volume reduction | Procedure | n this condition, we will reduce Tidal volume (with smartphone application calculation) to obtain the same alveolar ventilation (PaCO2) obtained on the HME condition |
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Cardiac echographic measurement (LeftVentricularEjectionFraction) in relation with acidosis status |
| Baseline, 30, 60, 90 and 120 minutes post intervention |
| Hemodynamic impact vs pH | Cardiac echographic measurement (RightVentricularEjectionFraction) in relation with acidosis status | Baseline, 30, 60, 90 and 120 minutes post intervention |
| Hemodynamic impact vs pH | Cardiac echographic measurement Arterial pulmonary pressure) in relation with acidosis status | Baseline, 30, 60, 90 and 120 minutes post intervention |
| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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