This is a prospective international multi-centre, observational cohort study of incident and prevalent patients diagnosed with a kidney disease

Inclusion Criteria:

1. Documented diagnosis of primary kidney disease

2. Regular visits (6-12 monthly) with a physician at a participating site that includes the monitoring of protein in urine and kidney function

3. eGFR > 25 ml/min/1.73m2

4. ≥ 2 to ≥ 80 years of age

5. One of the following laboratory urine parameters within 12 months of screening meeting the values of:

   • Urine Albumin-to-Creatinine Ratio (UACR) > 200 mg/g OR
   • Protein-to-Creatinine Ratio (PCR) > 300 mg/g OR
   • Albumin Excretion Rate (AER) > 200 mg/day OR
   • 24 hour Albumin Excretion > 200 mg/day OR
   • 24 hour Urine Protein Excretion > 300 mg/day

6. Willing and able to sign informed consent

7. Willing to be approached about participation in interventional research studies

Exclusion Criteria:

1. Life-expectancy of less than 6 months
2. Currently receiving renal replacement therapy or planned to start in the next 6 months
3. Planned transplant in the next 6 months
4. Currently participating in a clinical trial involving investigational medicinal product (exception is participation in studies implemented through the GKPTN)

Participants will be recruited from units that provide a comprehensive nephrology service

The current plan is that only aggregate data will be shared for research purposes. Individual participant data would only be reviewed in incidental findings and only be discussed with the participant in question.