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Cannabis is the most frequently consumed drug in France and its use continues to increase. Over the 18-64 age group as a whole, experimentation with cannabis at least once in a lifetime increased from 33% in 2010 to 42% in 2014, confirming the upward trend observed since the 1990.
Cannabis, like all drugs, disrupts the reward circuit whose neurons originate in the ventral tegmental area and project into the mesolimbic and cortical structures.
Acute cannabis use is thought to increase mesolimbic dopamine by affecting the Gabaergic or Glutamatergic system.
Chronic cannabis use usurps the reward system and leads to changes in the mesolimbic circuit (nucleus accumbens, ventral tegmental area, amygdala, and prefrontal cortex), inducing increased craving, with persistent craving for the substance and vulnerability to relapse.
Cognitively, addiction is associated with increased impulsivity, with a propensity to take risks leading to impaired decision-making.
There is currently no validated drug treatment for cannabis addiction. Non-invasive brain stimulation could be an interesting therapeutic alternative.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS active arm | Experimental |
| |
| tDCS placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuromodulation by tDCS | Other | The tDCS is a device for modulating cortical excitability. It consists of passing a low intensity direct electrical current over the scalp via two electrodes: an anode and a cathode soaked in a saline solution. Although there is a short-circuit effect through the scalp, a significant amount of electrical current enters the brain and changes the transmembrane potential. |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluating the change from craving to cannabis. by an analog visual scale .Scores (0 to 10) | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| The change to cannabis craving assessed by the Baseline Marijuana Craving Test at the end of treatment | 3 month | |
| The change in cannabis craving during an incentive to use task evaluated by analog visual scale scores (0 to 10) | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Youcef BENCHERIF | Contact | 0143093232 | y.bencherif@epsve.fr | |
| Rusheenthira THAVASEELAN | Contact | 0143093232 | r.thavaseelan@epsve.fr |
| Name | Affiliation | Role |
|---|---|---|
| Noomane BOUAZIZ | Clinical Unite research of EPS Ville Evrard | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Youcef BENCHERIF | Recruiting | Maisons-Alfort | Île-de-France Region | 94700 | France |
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double-blind randomized study
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|
| Montgomery-Åsberg depression rating scale) Scores (0 to 60) | 3 months |
| evaluation of the change in the number of joints consumed per day | 3 months |
| evaluation of the change in the number of cigarettes consumed per day | 3 months |
| assessment of the change in attention and inhibition skills as assessed by the Stroop test before and after a neurofeedback test | 3 months |
| the Gambling Task's assessment of decreased risk-taking | 3 months |
| Young Mania Rating Scale Scores (0 to 60) | 3 months |
| Beck Depression Inventory Scores (0 to 39) | 3 months |
| Clinical Global Impression Severity of disease (0 to 7) | 3 months |