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This study will describe the recovery process of patients undergoing cardiac surgery during the covid-19 pandemic. This will focus on hemodynamic failure and organ dysfunction after surgery.
Capturing real-world data and sharing international experience will inform the management of this complex group of patients who undergo surgery throughout the COVID-19 pandemic, improving their clinical care.
This investigator-led, non-commercial, non-interventional does not collect any patient identifiable information.
Performing cardiac surgery in the context of SARS-CoV2 infection is potentially at risk of marked post-operative hemodynamic failure (shock) due to the inflammatory reaction generated by the surgery and the extracorporeal circulation associated with the viral infection. In addition, in the absence of infection, 30-50% of patients will experience acute post-operative respiratory failure due to the combined effects of extracorporeal circulation and general anesthesia. The pulmonary tropism of the virus therefore is susceptible to increase in post-operative respiratory impairment.
Thus, the infection is likely to favor the occurrence of post-operative shock but also to aggravate respiratory failure and other post-operative organ failures.
Therefore, the investigators designed an observational study that aims at comparing two groups of patients:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cardiac or thoracic surgery in COVID-19 positive patients |
| ||
| Cardiac/thoracic surgery in COVID-19 negative patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | No description |
|
| Measure | Description | Time Frame |
|---|---|---|
| Highest VIS (Vasoactive-Inotropic Score) in the first 12 hours postoperatively. | The VIS score correlates with mortality after cardiac surgery and reflects the degree of patient hemodynamic failure. This score is calculated as follows: ISR = Dobutamine dose in g/kg/min + 100 times the Adrenaline dose in g/kg/min + 100 times the Noradrenaline dose in g/kg/min + 10,000 times the Vasopressin dose in U/kg/min. | 12 hours post-operatively |
| Measure | Description | Time Frame |
|---|---|---|
| Post-operative organ failure | Prospective assessment of ICU outcomes until all included patients were discharged from ICU | 5 days post-operatively |
| Post-operative outcome | Prospective assessment of ICU outcomes until all included patients. |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients undergoing cardiac or thoracic surgery during the COVID-19 pandemic.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mickael VOURC'H, MD | Contact | 0253482835 | vourchm@gmail.com | |
| Annick COULON | Contact | 0253482835 | bp-prom-regl@chu-nantes.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Recruiting | Nantes | 44093 | France |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| 28 days post-operatively |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |