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To identify and compare the differences in the concentration of the Muc2 and Muc5AC mucins in tear film in patients who underwent pterygium surgery using amniotic membrane transplantation and conjunctival autograft surgery.
Patients with nasal, primary pterygium bigger than 1 mm of corneal invasion with residence in Mexico City and older than 18 years were included. Under informed consent, patients were divided into two groups in a random fashion. Pterygium surgery was carried out with conventional technique performing amniotic membrane transplantation for group A, and conjunctival autograft for group B. Muc2 and muc5ac mucin concentration was measure min tear film by ELISA; samples were taken before surgery, at first, third and sixth month postoperatively. BUT was also measured on the same dates. Descriptive statistics and the U-Mann Whitney test for independent groups, considering a p≤0.05 as significant were used for analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Amniotic membrane transplantation | Active Comparator | Amniotic membrane transplantation was used as covering material in the area where the pterygium tissue was removed during the surgery. |
|
| conjnctival autograft. | No Intervention | Conjunctival autograft was used as a covering material in the area where the pterygium tissue was removed during the surgery. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Amniotic membrane transplantation | Procedure | Amniotic membrane transplantation was used as covering material during pterygium surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ocular Tear film Mucin MUC5ac concentration. | Using a capillary tube, tear film was collected en every patient. Then Concentration of mucin MUC5ac were measured by Elisa technique using a quantitative scale. | The patients will be assed during six months |
| Ocular tear film Mucin MUC2 concentration. | Using a capillary tube, tear film was collected en every patient. Then Concentration of mucin MUC2 were measured by Elisa technique using a quantitative scale. | The patients will be assed during six months |
| Tear film breakup time. | Tear film breakup time is the time between a complete blink and the appearance of the first random corneal dry spot and indicates relative tear film stability. | The patients will be assed during six months |
| Measure | Description | Time Frame |
|---|---|---|
| Pterygium recurrence. | Pterygium recurrence was defined as any fibrovascular proliferation from the original pterygium site from it was surgically removed. | The patients will be assed during six months |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D011625 | Pterygium |
| ID | Term |
|---|---|
| D003229 | Conjunctival Diseases |
| D005128 | Eye Diseases |
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Two groups of patients in whom Conventional Pterygium surgery was performed Each patient was randomly assigned for either received amniotic membrane transplantation or conjunctival autograft as a recovering method in the pterygium removed area after surgery. Tear film Mucins were measured in both groups
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The patients did not know what kind of material was used in their surgery. The assessor who performed tear film analysis did not know what material was used in the patient.