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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA047296 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women
The proposed study will compare smoked cannabis's dose-dependent, analgesic and abuse-related effects between men and women and variables that underlie these sex-dependent differences, including pharmacokinetics of THC.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Smoked Cannabis (~0% THC) |
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| Low strength cannabis | Experimental | Smoked Cannabis (~4% THC) |
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| Higher strength cannabis | Experimental | Smoked Cannabis (~10% THC) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Active Cannabis | Drug | Smoked cannabis with THC |
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| Measure | Description | Time Frame |
|---|---|---|
| Subject-rated drug effects | Average and peak subjective ratings of drug effects associated with abuse liability as measured using visual analogue scales (VAS; 1-100mm). | 5 hours |
| Analgesia as measured using the Cold Pressor Test | Peak and average pain threshold and tolerance assessed using the Cold Pressor Test | 5 hours |
| Pharmacokinetics of THC and metabolites | Plasma levels of THC, 11-OH-THC, and THCCOOH | 5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Drug reinforcement using the cannabis self-administration task | Average number of cannabis puffs self-administered as a function of cannabis strength and sex. For this task, up to three 'puffs' of cannabis may be chosen for self-administration during each session. | 5 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ziva Cooper, PhD | University of California, Los Angeles | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, Los Angeles | Los Angeles | California | 90095 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42009751 | Derived | Pabon E, Baglot SL, Eversole A, Fong T, Hampilos K, Hilger A, Lake S, Murray CH, Arout CA, Haney M, Tran A, Torrens A, Piomelli D, Cooper ZD. Cannabis use patterns and perception of acute pain during brief abstinence: sex-dependent associations with circulating cannabinoid levels. Psychopharmacology (Berl). 2026 Apr 21. doi: 10.1007/s00213-026-07063-2. Online ahead of print. |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D019966 | Substance-Related Disorders |
| D002189 | Marijuana Abuse |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D064419 | Chemically-Induced Disorders |
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This is a randomized, double-blind, placebo-controlled study. All participants will complete all dose conditions in a randomized order.
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| Placebo Cannabis | Drug | Placebo smoked cannabis (no THC) |
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| D001523 | Mental Disorders |