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We will study 40 matched patients. 20 patients will receive leukoreduced whole blood from the solid organ donor. These 20 patients will be compared to 20 historical matched controls with regards to allogenic blood product usage and other physiologic markers
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Donor Blood | Experimental | Between 2-4 units of donor leukoreduced whole blood (each unit will contain up to 350mL) transfused as needed in Liver transplantation participants |
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| Banked Blood | Active Comparator | Standard of Care - Up to 350mL Allogenic banked component blood transfusion in a 1:1:1 manner (packed red blood cells : plasma : platelets) transfused as needed in Liver transplantation participants |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Donor Blood | Biological | Up to 4 units (each unit contains 350mL) of leukoreduced donor whole blood |
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| Measure | Description | Time Frame |
|---|---|---|
| Use of allogenic banked blood products | Measured by the number of allogenic banked blood products used | perioperative up to 72 hours post operative |
| Economic cost | Total cost of perioperative transfusions | perioperative up to 72 hours post operative |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Serious Adverse Events (SAEs) | Number of deaths, life-threatening events, hospitalizations, disabilities or permanent damage, or congenital anomalies | Baseline to discharge (approximately 4-5 days) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Clayne Benson, MD | Vanderbilt University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vanderbilt University Medical Center | Nashville | Tennessee | 37205 | United States |
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20 recipients receive donor whole blood 20 historic match controls are compared to the 20 study participants
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| Banked Blood | Biological | Up to 350mL of Allogenic banked component blood transfusion in a 1:1:1 manner (packed red blood cells : plasma : platelets) |
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