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This study aims to investigate outcomes and predictors of outcome after extracorporeal membrane oxygenation (ECMO) therapy for severe acute respiratory syndrome (ARDS) in COVID-19 patients.
We evaluated the outcome of adult patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) requiring the use of extracorporeal membrane oxygenation (ECMO).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID-19 positive patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Extracorporeal membrane oxygenation | Device | Veno-venous or veno-arterial extracorporeal oxygenation |
|
| Measure | Description | Time Frame |
|---|---|---|
| In-hospital mortality | All-cause mortality | Immediately after the intervention/procedure/surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Death on ECMO | Death during ECMO therapy | During the intervention/procedure/surgery |
| Stroke | Stroke was defined as any focal or global neurological syndrome caused by ischemia and/or hemorrhage not resolving within 24 hours. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with PCR-confirmed or suspected COVID-19 infection with ARDS who require veno-venous or veno-arterial ECMO therapy
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| Name | Affiliation | Role |
|---|---|---|
| Fausto Biancari, Professor | Helsinki University Central Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Helsinki University Hospital | Helsinki | Finland | ||||
| University Hospital Jean Minjoz |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33573928 | Derived | Biancari F, Mariscalco G, Dalen M, Settembre N, Welp H, Perrotti A, Wiebe K, Leo E, Loforte A, Chocron S, Pacini D, Juvonen T, Broman LM, Perna DD, Yusuff H, Harvey C, Mongardon N, Maureira JP, Levy B, Falk L, Ruggieri VG, Zipfel S, Folliguet T, Fiore A. Six-Month Survival After Extracorporeal Membrane Oxygenation for Severe COVID-19. J Cardiothorac Vasc Anesth. 2021 Jul;35(7):1999-2006. doi: 10.1053/j.jvca.2021.01.027. Epub 2021 Jan 19. |
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| Immediately after the intervention/procedure/surgery |
| Blood stream infection | Blood stream infection detected on blood cultures | Immediately after the intervention/procedure/surgery |
| Lung complications requiring surgical treatment | Pneuthorax, pneumonia and/or abscess requiring surgical treatment | Immediately after the intervention/procedure/surgery |
| Blood transfusion | Transfusion of red blood cells | Immediately after the intervention/procedure/surgery |
| Acute kidney injury | Acute renal failure according to the Kidney Disease: Improving Global Outcomes classification (KDIGO) criteria | Immediately after the intervention/procedure/surgery |
| Duration of mechanical ventilation | Duration of mechanical ventilation | During index hospital stay follow-up until 1 year after ECMO initiation |
| Deep vein thrombosis | Thrombosis of lower limb deep venous system | Immediately after the intervention/procedure/surgery |
| Pulmonary embolism | Pulmonary embolism | Immediately after the intervention/procedure/surgery |
| Length of intensive care unit stay | Length of stay in the intensive care unit | Immediately after the intervention/procedure/surgery |
| Length of hospital stay | Length of hospital stay | Immediately after the intervention/procedure/surgery |
| Death after hospital discharge | All-cause death | Up to 6 months |
| Besançon |
| France |
| Nancy University Hospital | Nancy | France |
| Henri Mondon Unoversity Hospital | Paris | France |
| Robert Debré University Hospital | Reims | France |
| Hamburg University Heart Center | Hamburg | Germany |
| Münster University Hospital | Münster | Germany |
| S. Orsola Hospital | Bologna | Italy |
| Lecco Hospital | Lecco | Italy |
| Karolinska University Hospital | Stockholm | Sweden |
| University Hospitals of Leicester | Leicester | United Kingdom |
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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| ID | Term |
|---|---|
| D015199 | Extracorporeal Membrane Oxygenation |
| ID | Term |
|---|---|
| D012138 | Respiratory Therapy |
| D013812 | Therapeutics |
| D005112 | Extracorporeal Circulation |
| D013514 | Surgical Procedures, Operative |
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