Tadalafil Plus Tamsulosin for Male LUTS and ED

Prospective Observational Trial of Combination Therapy of Tadalafil 5mg Plus Tamsulosinmg for Men With Lower Urinary Tract Symptoms and Erectile Dysfunction

Metabolic Syndrome (MetS) is a complex epidemic disorder with an impact on both lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). Combination therapy of daily tadalafil and tamsulosin may provide relief to both diseases.

Aim of the present study is to assess the impact of combination therapy of Tadalafil 5mg plus Tamsulosin 0.4mg on LUTS and ED, according to presence vs. absence of Mets.

75 Consecutive men presenting with ED and LUTS suggestive of bladder prostatic obstruction were enrolled. Patients were divided into two groups according to MetS presence or absence. All subjects were then treated with tadalafil 5 mg/die plus tamsulosin 0.4 mg/die for 12 weeks. Patients were re-evaluated after 12 weeks of treatment with Uroflowmetry and PVR, IPSS, IPSS QoL, OAB-q and IIEF-5 and comparison were made in and between groups.

Inclusion Criteria:

• mild to severe ED (International Index of Erectile Function-Erectile Function-5 <22)
• moderate to severe LUTS (International Prostate Symptom Score >7)

Exclusion Criteria:

• hypersensitivity to tadalafil or tamsulosin
• prostatic cancer or suspected with prostate-specific antigen (PSA) >4 ng/mL
• bladder lithiasis
• previous prostatic surgery
• urinary tract infection
• neurogenic bladder
• finasteride or dutasteride use within 3 or 6 months respectively
• clinical history of urethral and/or proven bladder neck obstruction