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There are no universal treatment guidelines available. The ultimate purpose of the management of CSP is to simultaneously remove the pregnancy and successfully preserve the woman's fertility (Gonzalez & Tulandi, 2017). A variety of medical and surgical treatment modalities for CSP have been reported; however, most of these are based on low-level evidence(Sun et al., 2019).
This will be a randomized clinical trial to evaluate the effect of administration of methotrexate before surgery in reducing bleeding, injury to bladder and ureter, operative time and removing of CSP mass.This will be in comparison to surgery alone in cases of first trimester cesarean scar pregnancy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| surgery | Active Comparator |
|
|
| methotrexate before surgery | Active Comparator | Valid consent
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Methotrexate | Drug | giving methotrexate at least 1 w week before surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Estimated blood loss intraoperative | the amount of blood in soaked towels and vacuum aspiration | intraoperative blood loss |
| Measure | Description | Time Frame |
|---|---|---|
| need further management | 1 month | |
| • Rate of urological injury | immediatly and 1 week post operative | |
| • Rate of readmission, relaparotomy |
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Inclusion Criteria:•
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Maher Elesawi Elgaly, M.D MRCOG | Contact | +2 01016406182 | mahereleswi@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Maher Elgaly | Mansoura University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura University | Recruiting | Al Mansurah | Dakahliya | Egypt |
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| ID | Term |
|---|---|
| D000022 | Abortion, Spontaneous |
| D011271 | Pregnancy, Ectopic |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D008727 | Methotrexate |
| ID | Term |
|---|---|
| D000630 | Aminopterin |
| D011622 | Pterins |
| D011621 | Pteridines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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| with in 1 month |
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |