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A biobank has been created to investigate the prognostic value of biomarkers (mainly BNP) in patients implanted with durable mechanical assist devices comparing patients with advanced HF supported by MCS with those who are transplanted and those who remain on optimal medical therapy.
Patients will be followed up for 25 years after inclusion.
All patients referred for advanced HF treatment at the Dept of Cardiology at Rigshospitalet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MCS recipients | All recipients of durable MCS will be followed up on a yearly basis with collection of blood sample and clinical data for 25 years. |
| |
| Recipient of cardiac transplant | All recipients of cardiac transplantation(s) will be followed up on a yearly basis with collection of clinical data for 25 years. |
| |
| Watchful waiting at Rigshospitalet | Patients referred for evaluation for treatment with advanced treatment (LVAD/HTX) but -for whatever reason- these pts will be on watchful waiting at the Rigshospitalet. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observation. No intervention per se. | Other | Observation. No intervention (no collection of blood). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Alive | 25 years from inclusion | |
| Dead | Dead after inclusion in study | 25 years from inclusion |
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Inclusion Criteria:
Exclusion Criteria:
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All patients referred for evaluation for advanced HF treatment at the Rigshospitalet in Denmark. All patients with Advanced HF (regardless of type of adv HF treatment) at the contributing center will (hopefully) be included in this study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kiran Mirza, MD | Contact | +4535451442 | KiranMirza@dadlnet.dk | |
| Finn Gustafsson, MD, PhD, DMSci | Contact | +4535459743 | Finn.Gustafsson@regionh.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rigshospitalet | Recruiting | Copenhagen | DK | 2100 | Denmark |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D019370 | Observation |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
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|
| 2) Observation and collection and of blood sample | Other | All patients evaluated for adv HF (HTX/LVAD) will be offered to contribute to this database; Blood samples will be collected from all at baseline. Patients receiving LVAD will contribute on a yearly basis (or until withdrawal of consent). For other patients no further blood will be collected unless they receive an LVAD at a later point. |
|
|
| D019937 |
| Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |