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Analysis of localizations for symptoms and ischemia on treadmill and of the recovery profiles of patients that have had an exercise oximetry
Patients referred for exercise oximetry have buttocks thighs and calves recording during exercise and in the recovery period for a minimum of 10 minutes.
For each limb probe the decrease from rest of oxygen pressure (DROP) index is calculated as a subtraction of chest changes from limb changes throughout rest, exercise and recovery. DROP was measured as a routine on buttocks, thighs and calves and a minimal DROP lower than minus 15 mmHg considered indicative of the presence of regional blood flow impairment (ischemia) in the considered area.
Recordings and patients characteristics are recorded on a institutionally validated database.
A comparison will be performed of symptoms by history to symptoms reported on treadmill and hemodynamic results attained through DROP values.
Re-analysis of the recordings after ethical approval will be performed in an aim at estimating the duration of 50% and 90% recovery of DROP at the different levels (buttocks tigh and calves) to account for hemodynamic impairmenty not only at the calf (calves) level.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise oximetry | Patients complaining claudication and referred for exercise diagnostic oximetry. Exercise oximetry are performed on treadmill (3.2km/h, 10% slope) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcutaneous oxygen pressure measurement during the treadmill test | Diagnostic Test | Calculation of the decrease from rest of oxygen pressure (DROP) throughout the period of rest exercise and recovery. The DROP is calculated as chanegs on each limb probe minus changes on a chest reference probe from rest. Analysis of the recovery period of the recordings will be done to seach for recovery 50% and 90% from the minimal DROP observed Evaluation of calf and non calf pain during the tests. Evaluation of calf and non calf (buttock or thigh) ischemia during the tests. Ischemia being defined as a monimal DROP lower than minus 15 mmHg. |
| Measure | Description | Time Frame |
|---|---|---|
| Transcutanesous oximetry DROP index 50% recovery time | Time for the DROP index to reach 50% of its minimal value from the end of walking | Maximum 30 minutes (duration of the recovery phase) |
| Measure | Description | Time Frame |
|---|---|---|
| Transcutanesous oximetry DROP index 90% recovery time | Time for the DROP index to reach 90% of its minimal value from the end of walking | Maximum 30 minutes (duration of the recovery phase) |
| Concordance of pain and ischemia during the treadmill test |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients referred for exercise oximetry for intermittent claudication
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| Name | Affiliation | Role |
|---|---|---|
| Pierre ABRAHAM, MD; PhD | UH in Angers (FRANCE) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Angers | 49933 | France |
Data available under reasonable request
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| ID | Term |
|---|---|
| D007383 | Intermittent Claudication |
| ID | Term |
|---|---|
| D058729 | Peripheral Arterial Disease |
| D016491 | Peripheral Vascular Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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|
Observation of calf and non calf pain and calf and non-calf ischemia in patients reporting calf pain by history. Ischemia being defined as a minimal DROP value lower than minus 15 mmHg.
Analysis of the concordance of localizations of pain and ischemia.
| Maximum 60 minutes (duration of each test) |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |