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Patients older than 60 years are more and more transplanted. Comprehensive geriatric assessment (CGA) have been developed and are currently used in patients with cancer, it has been correlated with the prognosis. There is still few data in transplanted patients and the aim of this study is to assess these patients before and after transplantation in order to monitor their general health and quality of life (QOF) and correlate them to the prognostic.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Comprehensive geriatric assessment (CGA) | Other | Questionnaires on nutritional status, autonomy and quality of life |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | at one year post allogeneic hematopoietic stem cell transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | at two years post allogeneic hematopoietic stem cell transplantation | |
| Morbidity Index | at one year | |
| Morbidity Index |
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Inclusion Criteria:
Exclusion Criteria:
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Patients over 60 years who received an allogeneic hematopoietic stem cell transplantation HSCT
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens | Amiens | France | ||||
| CHU Angers |
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| at two years |
| Survival without disease and chronic graft-versus-host disease | at one year post allogeneic hematopoietic stem cell transplantation |
| Survival without disease and chronic graft-versus-host disease | at two years post allogeneic hematopoietic stem cell transplantation |
| Proportion of patient with Viral Reactivation | Reactivation of cytomegalovirus (CMV) or Epstein-Barr virus (EBV) virus | at one year |
| Acute graft-versus-host disease | at 100 days |
| Chronic graft-versus-host disease | at 1 year |
| Chronic graft-versus-host disease | at 2 years |
| Incidence of relapse | at two years |
| Walk test | Walk tests measure the functional level of patients suffering from a wide range of cardiac, respiratory, neurological, and musculoskeletal conditions. | at day 100 |
| Walk test | Walk tests measure the functional level of patients suffering from a wide range of cardiac, respiratory, neurological, and musculoskeletal conditions. | at one year |
| Walk test | Walk tests measure the functional level of patients suffering from a wide range of cardiac, respiratory, neurological, and musculoskeletal conditions. | at two years |
| Nutritional score | Nutrional score will be assessed using the simple evaluation of food intake (SEFI scale). The minimum value is 0 and the maximum is 10. The highest score mean that the patient's food intake are the same as usual. | at day 100 |
| Nutritional score | Nutrional score will be assessed using the simple evaluation of food intake (SEFI scale). The minimum value is 0 and the maximum is 10. The highest score mean that the patient's food intake are the same as usual. | at one year |
| Nutritional score | Nutrional score will be assessed using the simple evaluation of food intake (SEFI scale). The minimum value is 0 and the maximum is 10. The highest score mean that the patient's food intake are the same as usual. | at two years |
| Karnofsky index | The Karnofsky index is a synthetic indicator of the overall health status measuring, on a scale from 0 (death) to 100 (full health) | at day 100 |
| Karnofsky index | The Karnofsky index is a synthetic indicator of the overall health status measuring, on a scale from 0 (death) to 100 (full health) | at one year |
| Evaluation of autonomy | Autonomy will be evaluated using ADL and IADL score. Instrumental activities of daily living - global score range from 0 to 4. | at one year |
| Evaluation of Quality of life | Quality of life evaluated using questionnaire "European Organization for Research and Treatment of Cancer Quality of Life Questionnaire" (EORTC QLQ-C30- v3). The QLQ-C30 is composed of both multi-item scales and single-item measures. These include five functional scales, three symptom scales, a global health status / QoL scale, and six single items. Each of the multi-item scales includes a different set of items - no item occurs in more than one scale. All of the scales and single-item measures range in score from 0 to 100. A high scale score represents a higher response level. A high score for a functional scale represents a high/healthy level of functioning. A high score for the global health status/ QoL represents a high QoL and a high score for a symptom scale/item represents a high level of symptomatology/problems. EORTC QLQ-C30 Scoring Manual. Fayers PM et al. on behalf of the EORTC Quality of Life Group. EORTC, 2001. ISBN: 2-9300. | at one year |
| Length of hospitalisation initially | at two years |
| Length of hospitalisation during the first year after graft | Up to one year |
| Questionnaire completion rate | At 2 years |
| Length of pre-grafting visit | At 2 years |
| Length of D100 visit | At 2 years |
| Length of 1year visit | At 2 years |
| Length of 2 years visit | At 2 years |
| Angers |
| France |
| CHU Besancon | Besançon | France |
| CHU Bordeaux | Bordeaux | France |
| CHU Caen | Caen | France |
| CHU Clermont-Ferrand | Clermont-Ferrand | France |
| CHU Grenoble | Grenoble | France |
| CHRU Lille | Lille | France |
| CHU Limoges | Limoges | France |
| CHU Lyon | Lyon | France |
| CHU Montpellier | Montpellier | France |
| CHRU Nancy | Nancy | France |
| CHU Nantes | Nantes | France |
| CHU Nice | Nice | France |
| Hopital de la Pitié Salpetrière | Paris | France |
| Hopital Necker | Paris | France |
| Hopital Saint Louis | Paris | France |
| CHU Toulouse | Toulouse | France |
| ID | Term |
|---|---|
| D015577 | Geriatric Assessment |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D006304 | Health Status |
| D003710 | Demography |
| D011154 | Population Characteristics |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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