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The aim of this study is to evaluate the periodontal outcomes after applying antimicrobial photodynamic therapy with a novel photosensitizer as compared to LASER assisted scaling and root planing alone.
LASER assisted SRP followed by antimicrobial photodynamic therapy with a novel photosensitizer dye Phthalocyanine will be done in test group subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| main treatment group | Experimental | LASER assisted SRP followed by antimicrobial photodynamic therapy with a novel photosensitizer dye Phthalocyanine |
|
| control group | Placebo Comparator | LASER assisted SRP |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phthalocyanine Dye | Drug | following LASER assisted SRP, a novel photosensitizer phthalocyanine dye will be placed |
|
| Measure | Description | Time Frame |
|---|---|---|
| Release profile of the drug | Release profile of the drug in Gingival Crevicular Fluid (GCF) samples will be evaluated through biochemical testing kits. | Change from baseline to 7-days. |
| probing pocket depths (PPD) | Assessment of probing pocket depths (PPD, in mm) by using a manual periodontal probe on six sites (mesiobuccal, midbuccal, distobuccal, mesiolingual, midlingual and distolingual) will be performed. | Change from baseline to 6-months. |
| clinical attachment level (CAL) | Assessment of clinical attachment level (CAL, in mm) by using a manual periodontal probe on six sites (mesiobuccal, midbuccal, distobuccal, mesiolingual, midlingual and distolingual) will be performed. | Change from baseline to 6-months. |
| Measure | Description | Time Frame |
|---|---|---|
| plaque index (PI) | Assessment of plaque (PI) - according to Turesky modification of Quigley and Hein Plaque Index; 0-No plaque 1-Isolated flecks of plaque at the gingival margin 2-A continuous band of plaque up to 1mm at the gingival margin 3-Plaque greater than 1mm in width and covering up to one third of the tooth surface 4-Plaque covering from one thirds to two thirds of the tooth surface 5-Plaque covering more than two thirds of the tooth surface. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| RVchandra, MDS; DNB | Contact | 9908183071 | viswachandra@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| R V Chandra | Recruiting | Hyderabad | Telangana | 509002 | India |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D016301 | Alveolar Bone Loss |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D001862 | Bone Resorption |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| LASER assisted SRP | Drug | LASER assisted SRP will be carried |
|
|
| Change from baseline to 6-months. |
| bleeding on probing (BOP) | Assessment of bleeding on probing (BOP) as a dichotomous variable ("Yes"/"No") by using a manual periodontal probe. | Change from baseline to 6-months. |
| SVS Institute of Dental Sciences | Recruiting | Hyderabad | Telangana | 509002 | India |
|
| D001847 |
| Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D055093 | Periodontal Atrophy |
| D008722 | Methods |