An Open-Label, Multicenter, Rollover Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants With Alzheimer's Disease
An Open-Label, Multicenter, Rollover Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants With Alzheimer's Disease
This is an open-label, multicenter, rollover study to evaluate the safety, tolerability, and efficacy of long-term administration of open-label gantenerumab in participants with AD who completed Study WN29922 or WN39658, either the double-blind or open-label extension (OLE) part.
Participants who were in the active arm in the double blind part and those who have completed OLE part in the parent study, will continue receive open-label gantenerumab 510 mg sub-cutaneously (SC) every 2 weeks (Q2W). Participants who are naive to gantenerumab treatment will be required to undergo the 3 step uptitration scheme as in the parent study before receiving target dose of open label gantenerumab.
Inclusion Criteria:
Exclusion Criteria:
Boston, Massachusetts 02115, United States
Omaha, Nebraska 68198-8440, United States
Cleveland, Ohio 44195, United States
Houston, Texas 77030, United States
CABA, C1199ABB, Argentina
Caba, C1405BCK, Argentina
Capital Federal, C1427CCP, Argentina
Heidelberg West, Victoria 3081, Australia
Curitiba, Paraná 80810-040, Brazil
Amiens Cedex1, 80054, France
Berlin, 12200, Germany
Berlin, 13125, Germany
Cologne, 50937, Germany
Mainz, 55131, Germany
München, 81675, Germany
Modena, Emilia-Romagna 41126, Italy
Turin, Piedmont 10126, Italy
Palermo, Sicily 90127, Italy
Monterrey, Nuevo León 64460, Mexico
?cinawa, 59-330, Poland
Bia?ystok, 15-756, Poland
Wroc?aw, 53-659, Poland
Krasnoyarsk, Krasnoyarsk Krai 660037, Russia
Moscow, Moscow Oblast 121467, Russia
Moscow, Moscow Oblast 125101, Russia
Moskva, Moscow Oblast 117556, Russia
Saint Petersburg, Sankt-Peterburg 194044, Russia
Kazan', Tatarstan Republic 420101, Russia
L'Hospitalet de Llobregat, Barcelona 08907, Spain
Santander, Cantabria 39011, Spain
Móstoles, Madrid 28938, Spain
Mölndal, 431 41, Sweden
Changhua County, 500, Taiwan
Niaosong Dist., 83301, Taiwan
North Dist., 40447, Taiwan
Cheltenham, GL53 9DZ, United Kingdom
Chertsey, KT16 9AU, United Kingdom
Sheffield, S10 2JF, United Kingdom