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Departure of the investigator who was recruiting subjects
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The study ARITH22 will investigate the role of visuo-spatial attention on arithmetic abilities of children with 22q11.2 deletion syndrome.
Children with 22q11.2 deletion syndrome often have arithmetic learning disability because of magnitude representation impairment. Previous works suggested that magnitude representation impairment could be a result of endogenous visuo-spatial attention dysfunction in 22q11.2DS. Nevertheless this relationship is still poor explored. The influence of visuo-spatial abilities on arithmetic achievement could also be modulated by developmental age. The study ARITH22 will test these hypotheses thanks to magnitude comparisons tasks, in children with 22q11.2 deletion syndrome and matched children without developmental disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 22q11.2DS | Experimental | Children aged from 4 to 11 years old with 22q11.2 deletion syndrome |
|
| NON22q11.2DS | Active Comparator | Children aged from 4 to 11 years old without developmental disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnitude comparison tasks and neuropsychological testing | Behavioral | neuropsychological testing (ZAREKI-R) and magnitude comparison tasks with stimuli of different types (visual, visuo-spatial) |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of impaired scaled score | percentage of impaired scaled score at ZAREKI-R | single day |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of correct responses | percentage of correct responses in magnitude comparisons tasks | single day |
| Mean reaction time | mean reaction time in magnitude comparison tasks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Caroline DEMILY, MD PH | Centre Hospitalier le Vinatier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital Vinatier | Lyon | Auvergne-Rhône-Alpes | 69678 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38961462 | Derived | Favre E, Piveteau M, Babinet MN, Demily C. Extent of magnitude representation deficit and relationship with arithmetic skills in children with 22q11.2DS. Orphanet J Rare Dis. 2024 Jul 3;19(1):250. doi: 10.1186/s13023-024-03263-1. |
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| ID | Term |
|---|---|
| D004062 | DiGeorge Syndrome |
| ID | Term |
|---|---|
| D058165 | 22q11 Deletion Syndrome |
| D019465 | Craniofacial Abnormalities |
| D009139 | Musculoskeletal Abnormalities |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
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Monocentric study with two parallel groups
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| single day |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D044148 | Lymphatic Abnormalities |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D000015 | Abnormalities, Multiple |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D025063 | Chromosome Disorders |
| D030342 | Genetic Diseases, Inborn |
| D007011 | Hypoparathyroidism |
| D010279 | Parathyroid Diseases |
| D004700 | Endocrine System Diseases |