Impact of TAVI on Cognition, Mood and Health-related Quality of Life

The Impact of Transcatheter Aortic Valve Implantation on Cognition, Mood and Health-related Quality of Life - an Explorative Study

In the proposed study, patients with and without embolic protection devices during Transcatheter Aortic Valve Implantation will be repeatedly examined with a comprehensive psychiatric and cognitive test battery over a post-interventional period of 6 months after TAVI, with regard to the effects on mood, cognitive Performance and health-related Quality of life.

The percutaneous aortic valve replacement (TAVI, Transcatheter Aortic Valve Implantation) enables the implantation of a new biological aortic valve at the beating heart. The procedure is performed under local anaesthesia and is a gold standard in the therapy of aortic stenosis, especially in patients with a too high health risk for cardiovascular surgery.

In the proposed study, patients with and without embolic protection devices during TAVI will be repeatedly examined with a comprehensive psychiatric and cognitive test battery over a post-interventional period of 6 months after TAVI, with regard to the effects on mood, cognitive Performance and health-related quality of life.

Inclusion Criteria:

• Written declaration of consent of the study participants to participate in the study after detailed information on the nature, significance, risks and scope of the study.
• Women and men between the ages of 19 and 90
• Clinical indication for TAVI intervention
• No previous psychiatric illness before TAVI
• No other serious disease affecting the immune system

Exclusion Criteria:

• Non-compliance with the inclusion criteria
• Persons unable to give consent (e.g. dementia, delirium etc.)
• Magnetic resonance imaging (MR) contraindications
• ophthalmological inability to read