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| Name | Class |
|---|---|
| Josip Juraj Strossmayer University of Osijek | OTHER |
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Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients. The investigators compared the outcomes of participants with low creatinine levels with subsequent ICU participants admitted into ICU in the tertiary hospital.
The investigators have found a total of 46 participants with low creatinine levels and compared their outcome data with a group of participants with normal or high creatinine levels (control group, N=61). Low creatinine was defined as values of ≤40 μmol/L. Demographic data, type of admission (medical vs. surgical), hemoglobin values, CRP, and ventilator days were compared. A statistical analysis was performed using chi square and T-test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | Total of 46 patients with low serum creatinine levels whose values were obtained from the central laboratory with inclusion criteria (< 40mmol/L) |
| |
| Control group | A total of 61 consecutive patients were obtained who were treated in ICU CHC Osijek, according to the date of admission. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Serum creatinine levels | Diagnostic Test | Comparison of treatment length using mechanical ventilaton, length of stay in ICU, survival between two groups |
|
| Measure | Description | Time Frame |
|---|---|---|
| Length of mechanical ventilation treatment in group with low serume creatinine level | The investigators compared length of mechanical ventilation treatment between group with low serume creatinine level and control group | Through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Length of stay in ICU in group with low serume creatinine level | The investigators compared length of stay in ICU between group with low serume creatinine level and control group | Through study completion, an average of 1 year |
| White blood cell values in group with low creatinine level |
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Inclusion Criteria:
Exclusion Criteria:
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Study group was selected by measuring low serume creatinine levels (≤40 µmol/L) during the treatment in ICU. Control group was obtained by consecutive selection of patients according to the date of admission to the ICU.
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| Name | Affiliation | Role |
|---|---|---|
| Slavica Kvolik, MD; PhD. | Osijek University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital centre Osijek | Osijek | 31000 | Croatia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25361907 | Background | Vo P, Kharasch VS. Respiratory failure. Pediatr Rev. 2014 Nov;35(11):476-84; quiz 485-6. doi: 10.1542/pir.35-11-476. | |
| 25201432 | Background | Briones Claudett KH. Noninvasive ventilation in the event of acute respiratory failure in patients with idiopathic pulmonary fibrosis: waiting for? J Crit Care. 2014 Dec;29(6):1128. doi: 10.1016/j.jcrc.2014.07.016. Epub 2014 Jul 22. No abstract available. |
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All the data recorded will be available after the manuscript will be published, upon the request by stjepan.grga.milankovic@gmail.com
After the publication of the manuscript in the medical journal
Free available to anyone
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| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D018908 | Muscle Weakness |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
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The investigators compared white blood cell values between group with low creatinine level and control group |
| Through study completion, an average of 1 year |
| Hemoglobine values in group with low creatinine level | The investigators compared hemoglobine values between group with low creatinine level and control group | Through study completion, an average of 1 year |
| Number of patients who started nutrition in ICU | The investigators compared number of patients between group with low creatinine level and control group who started nutrition in ICU | Through study completion, an average of 1 year |
| Platelets values in group with low creatinine level | The investigators compared platelet values between group with low creatinine level and control group | Through study completion, an average of 1 year |
| Number of patients who receive blood products transfusion | The investigators compared number of patients who received blood products between group with low creatinine level and control group | Through study completion, an average of 1 year |
| Number of patients discharged | The investigators compared number of patients who were discharged from intensive care unit to the ward between group with low creatinine level and control group | Through study completion, an average of 1 year |
| 25110463 | Background | Schwabbauer N, Berg B, Blumenstock G, Haap M, Hetzel J, Riessen R. Nasal high-flow oxygen therapy in patients with hypoxic respiratory failure: effect on functional and subjective respiratory parameters compared to conventional oxygen therapy and non-invasive ventilation (NIV). BMC Anesthesiol. 2014 Aug 7;14:66. doi: 10.1186/1471-2253-14-66. eCollection 2014. |
| 9151520 | Background | Zielinski J, MacNee W, Wedzicha J, Ambrosino N, Braghiroli A, Dolensky J, Howard P, Gorzelak K, Lahdensuo A, Strom K, Tobiasz M, Weitzenblum E. Causes of death in patients with COPD and chronic respiratory failure. Monaldi Arch Chest Dis. 1997 Feb;52(1):43-7. |
| 28442589 | Background | Pettenuzzo T, Fan E. 2016 Year in Review: Mechanical Ventilation. Respir Care. 2017 May;62(5):629-635. doi: 10.4187/respcare.05545. |
| 27842754 | Background | Sahetya S, Allgood S, Gay PC, Lechtzin N. Long-Term Mechanical Ventilation. Clin Chest Med. 2016 Dec;37(4):753-763. doi: 10.1016/j.ccm.2016.07.014. Epub 2016 Oct 14. |
| 17855814 | Background | De Jonghe B, Bastuji-Garin S, Durand MC, Malissin I, Rodrigues P, Cerf C, Outin H, Sharshar T; Groupe de Reflexion et d'Etude des Neuromyopathies en Reanimation. Respiratory weakness is associated with limb weakness and delayed weaning in critical illness. Crit Care Med. 2007 Sep;35(9):2007-15. doi: 10.1097/01.ccm.0000281450.01881.d8. |
| 27179057 | Background | Datta D, Foley R, Wu R, Grady J, Scalise P. Can Creatinine Height Index Predict Weaning and Survival Outcomes in Patients on Prolonged Mechanical Ventilation After Critical Illness? J Intensive Care Med. 2018 Feb;33(2):104-110. doi: 10.1177/0885066616648133. Epub 2016 May 13. |
| 24015310 | Background | Lai YC, Ruan SY, Huang CT, Kuo PH, Yu CJ. Hemoglobin levels and weaning outcome of mechanical ventilation in difficult-to-wean patients: a retrospective cohort study. PLoS One. 2013 Aug 28;8(8):e73743. doi: 10.1371/journal.pone.0073743. eCollection 2013. |
| 22976446 | Background | Lee JJ, Waak K, Grosse-Sundrup M, Xue F, Lee J, Chipman D, Ryan C, Bittner EA, Schmidt U, Eikermann M. Global muscle strength but not grip strength predicts mortality and length of stay in a general population in a surgical intensive care unit. Phys Ther. 2012 Dec;92(12):1546-55. doi: 10.2522/ptj.20110403. Epub 2012 Sep 13. |
| 26348431 | Background | Ellis CS. Improving Nutrition in Mechanically Ventilated Patients. J Neurosci Nurs. 2015 Oct;47(5):263-70; quiz E1. doi: 10.1097/JNN.0000000000000161. |
| 27207177 | Background | Coudroy R, Jamet A, Petua P, Robert R, Frat JP, Thille AW. High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: an observational cohort study. Ann Intensive Care. 2016 Dec;6(1):45. doi: 10.1186/s13613-016-0151-7. Epub 2016 May 20. |
| 22699745 | Background | Weiler N, Waldmann J, Bartsch DK, Rolfes C, Fendrich V. Outcome in patients with long-term treatment in a surgical intensive care unit. Langenbecks Arch Surg. 2012 Aug;397(6):995-9. doi: 10.1007/s00423-012-0966-0. Epub 2012 Jun 15. |
| 26975785 | Background | van Vught LA, Klein Klouwenberg PM, Spitoni C, Scicluna BP, Wiewel MA, Horn J, Schultz MJ, Nurnberg P, Bonten MJ, Cremer OL, van der Poll T; MARS Consortium. Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis. JAMA. 2016 Apr 12;315(14):1469-79. doi: 10.1001/jama.2016.2691. |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |