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Efficacy of tranexamic acid on blood loss during percutaneous nephrolithotomy. a double-blind, placebo-controlled randomized clinical trial.
To evaluate whether intravenous tranexamic acid or tranexamic acid in the irrigation fluid in percutaneous nephrolithotomy (PCNL) in reducing bleeding during and after PCNL.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tranexamic acid local | Active Comparator | tranexamic acid inside the irrigation fluid |
|
| tranexamic acid IV | Active Comparator | tranexamic acid injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic acid injection | Drug | hemostatics use |
|
| Measure | Description | Time Frame |
|---|---|---|
| To assess the value of tranexamic acid | To compare the efficacy and safety of 0.1% IV tranexamic acid versus inside the irrigant fluid tranexamic acid in reducing blood loss during PCNL. Moreover, to assess the adverse events of tranexamic acid. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Hemoglobin drop post PCNL. | Assess fall percentage in hemoglobin drop. | 12 months |
| Requirement of blood transfusion post PCNL. | assess the total blood loss and requirement of blood transfusion post PCNL. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Diaa Eldin Taha, MD | Contact | 01008531384 | drdiaaeldin@gmail.com | |
| Hossam Nabeeh, MD | Contact | dr_hossam_nabeeh@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Diaa Eldin Taha, MD | Lecturer of urology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kafrelsheikh faculty of medicine | Recruiting | Kafr ash Shaykh | Kafrelsheikh | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37882229 | Derived | Cleveland B, Norling B, Wang H, Gandhi V, Price CL, Borofsky MS, Pais V, Dahm P. Tranexamic acid for percutaneous nephrolithotomy. Cochrane Database Syst Rev. 2023 Oct 26;10(10):CD015122. doi: 10.1002/14651858.CD015122.pub2. |
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| ID | Term |
|---|---|
| D053040 | Nephrolithiasis |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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tranexamic acid during and after percutanous nephrolithotomy procedure
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randomization
| 12 months |
| D000091642 | Urogenital Diseases |
| D052878 | Urolithiasis |
| D052801 | Male Urogenital Diseases |