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| Name | Class |
|---|---|
| Public Health England | OTHER_GOV |
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Analysis of women's medical records to understand the impact of previous changes to breast cancer screening (increase from one to two clinicians examining each woman's mammograms, and what proportion of women they recall for further tests)
Retrospective observational study examining the records and outcomes of women who attended breast cancer screening between 1988 and 2016. Linkage of records from the breast screening service, the cancer registry, and mortality. Analysis of whether changing the threshold for whether to recall women for further tests or the number of clinicians examining the mammograms for signs of cancer affects outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single reading | Only one clinician examined the woman's mammograms for signs of cancer and recommended whether to recall her for further tests or not. |
| |
| Double reading | Two clinicians examined the woman's mammograms for signs of cancer and recommended whether to recall her for further tests or not. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Breast Screening Mammography with single reader | Diagnostic Test | One clinician examined each woman's mammograms for signs of cancer |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of women overdiagnosed (the cancer would not have become symptomatic within the woman's lifetime) using compensatory drop method | Overdiagnosis of breast cancer (measured as difference in total cancer incidence, screen and symptomatic). Will also report mechanism of action (number of screen detected cancers, number of symptomatically detected cancers at 3,13, and 30 years follow-up) | 13 years, and up to 30 years |
| Cancers detected at screening | Biopsy proven cancers detected at screening | 1 day screening episode |
| False positive recalls | Recall of women for further tests after screening which did not result in detection of cancer | 1 day screening episode |
| Breast cancer mortality | Mortality due to breast cancer (dependent on securing follow-on funding) | 13 years, and up to 30 years |
| All cause mortality | Mortality due to any cause (dependent on securing follow on funding) | 13 years, and up to 30 years |
| Characteristics of cancer detected | Size, grade and stage (reported overall, screen detected, and symptomatic detected). | 1 day screening episode, 3year, 13 year and up to 30 year follow up |
| Measure | Description | Time Frame |
|---|---|---|
| Breast cancer morbidity | Treatment received as a proxy for treatment associated morbidity (reported overall, screen detected and symptomatically detected, if follow on funding obtained) | Up to 30 years |
| Breast cancer free survival |
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Inclusion Criteria:
Exclusion Criteria:
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Women who attended the English NHS Breast screening programme between 1988 and 2016 aged between 47 and 73.
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| Name | Affiliation | Role |
|---|---|---|
| Sian Taylor-Phillips, PhD | University of Warwick | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Univesity of Warwick | Coventry | Warwickshire | CV47AL | United Kingdom |
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| Label | URL |
|---|---|
| Study website | View source |
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We do not have Office of Data Release permissions to share these data with other researchers
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| D002285 | Carcinoma, Intraductal, Noninfiltrating |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D013069 | Speech Reception Threshold Test |
| ID | Term |
|---|---|
| D001302 | Audiometry, Speech |
| D001299 | Audiometry |
| D006320 | Hearing Tests |
| D003939 | Diagnostic Techniques, Otological |
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| Breast screening mammography with two readers | Diagnostic Test | Two clinicians seperately examined each woman's mammograms for signs of cancer |
|
| Test threshold | Diagnostic Test | Threshold used by readers examining the breast screening mammograms, defined using their previous proportion of cases recalled |
|
Survival without a diagnosis of breast cancer
| Up to 30 years follow-up |
| D017437 |
| Skin and Connective Tissue Diseases |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D000071960 | Breast Carcinoma In Situ |
| D002278 | Carcinoma in Situ |
| D018299 | Neoplasms, Ductal, Lobular, and Medullary |
| D019937 |
| Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |