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| Name | Class |
|---|---|
| Guy's and St Thomas' NHS Foundation Trust | OTHER |
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This is a prospective observational cohort study of healthcare workers working in high-risk COVID-19 clinical areas, monitoring heart rate, sleep and temperature, correlating with daily self-reported symptoms, oxygen saturations and PCR Swabs. It will provide information about how many healthcare workers develop COVID-19, what their clinical observations and symptoms are.
During the COVID-19 Pandemic, doctors and other healthcare workers who work in COVID+ wards, intensive care unit and the accident and emergency department are at high risk of developing COVID-19 infection.
In April 2020, 14.6% of doctors were off sick with suspected or confirmed COVID-19 infection. Meanwhile, 17.9% of COVID+ patients are thought to be asymptomatic. Therefore, healthcare workers are also high-risk of spreading infection to patients, colleagues and their families.
This is a prospective observational cohort study that leverages wearable medical device technology and data analytics to develop an algorithm for early detection of COVID-19 infection in healthcare workers.
A total of 60 healthy healthcare workers working within high-risk COVID-19 clinical areas will be asked to wear a wearable medical device that measures their heart rate, skin temperature and sleep during non-working hours. They will take daily swabs for COVID-19 from themselves, measure their oxygen levels daily, and answer a survey of self-reported symptoms daily for the 30 day study period.
These will then be analyzed to develop an algorithm for early detection of COVID-19 in healthcare workers, and help to inform future workforce decisions, to promote welfare and prevent the spread of COVID-19.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wearable Medical Device (Empatica E4) | Device | A wearable medical device (Empatica E4) which is a smart wristband that detects skin temperature, heart rate and sleep. It is CE and FDA approved. | ||
| COVID-19 PCR Swab | Diagnostic Test | COVID-19 PCR Swab will be self-taken by doctors every day. Fischer nasopharyngeal PCR Swabs | ||
| Pulse Oximeter | Diagnostic Test | Participants will measure their oxygen saturations every day, and report them on the survey. Pulmolink A310 pulse oximeters |
| Measure | Description | Time Frame |
|---|---|---|
| COVID-19 Infection | Number of Healthcare Workers who have a new PCR positive diagnosis of COVID-19 | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Symptoms | What new symptoms healthcare workers develop when they develop COVID-19 infection | 30 days |
| Clinical Observations | What healthcare workers observations are when they develop COVID-19 infection including: Oxygen saturations, Heart Rate, Skin Temperature |
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Inclusion Criteria
Exclusion Criteria
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Healthy healthcare workers who work in high-risk COVID-19 areas, and have not themselves had a PCR/Antibody positive diagnosis of COVID-19
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kariem El-Boghdadly, FRCA | Contact | 020 7188 7188 | kariem.elboghdadly@gstt.nhs.uk | |
| Alexander Zargaran, MBBS, BSc | Contact | 020 7188 7188 | alexander.zargaran@kcl.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Alexander Zargaran, MBBS | King's College London / Guy's and St Thomas' NHS Foundation Trust | Study Director |
| Anne Greenough | King's College London | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guy's and St Thomas' NHS Foundation Trust | Recruiting | London | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40187781 | Derived | Zargaran A, Sousi S, Colville G, Radcliffe G, Malek R, Douiri A, El-Boghdadly K, Nebbia G, Martinez Nunez RT, Greenough A. COVID-19 Early Detection in Doctors and Healthcare Workers (CEDiD) study: a cohort study on the feasibility of wearable devices. BMJ Open. 2025 Apr 5;15(4):e089598. doi: 10.1136/bmjopen-2024-089598. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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COVID-19 PCR Swabs
| 30 days |
| Dina Radenkovic, MBBS |
| King's College London / Guy's and St Thomas' NHS Foundation Trust |
| Study Director |
| Rocio Martinez-Nunez, PhD | King's College London | Study Director |
| Kariem El-Boghdadly | Guy's and St Thomas' NHS Foundation Trust | Principal Investigator |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |